Spelbrink JN - Search Results

1

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.

Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG. Trifunovic A, et al. Among authors: spelbrink jn. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8. doi: 10.1073/pnas.0508886102. Epub 2005 Dec 6. Proc Natl Acad Sci U S A. 2005. PMID: 16332961 Free PMC article.

2

Premature ageing in mice expressing defective mitochondrial DNA polymerase.

Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG. Trifunovic A, et al. Among authors: spelbrink jn. Nature. 2004 May 27;429(6990):417-23. doi: 10.1038/nature02517. Nature. 2004. PMID: 15164064

3

Sequence-specific stalling of DNA polymerase γ and the effects of mutations causing progressive ophthalmoplegia.

Atanassova N, Fusté JM, Wanrooij S, Macao B, Goffart S, Bäckström S, Farge G, Khvorostov I, Larsson NG, Spelbrink JN, Falkenberg M. Atanassova N, et al. Among authors: spelbrink jn. Hum Mol Genet. 2011 Mar 15;20(6):1212-23. doi: 10.1093/hmg/ddq565. Epub 2011 Jan 12. Hum Mol Genet. 2011. PMID: 21228000

4

No sex please, we're mitochondria: a hypothesis on the somatic unit of inheritance of mammalian mtDNA.

Jacobs HT, Lehtinen SK, Spelbrink JN. Jacobs HT, et al. Among authors: spelbrink jn. Bioessays. 2000 Jun;22(6):564-72. doi: 10.1002/(SICI)1521-1878(200006)22:6<564::AID-BIES9>3.0.CO;2-4. Bioessays. 2000. PMID: 10842310 Review.

5

Human mtDNA sublimons resemble rearranged mitochondrial genoms found in pathological states.

Kajander OA, Rovio AT, Majamaa K, Poulton J, Spelbrink JN, Holt IJ, Karhunen PJ, Jacobs HT. Kajander OA, et al. Among authors: spelbrink jn. Hum Mol Genet. 2000 Nov 22;9(19):2821-35. doi: 10.1093/hmg/9.19.2821. Hum Mol Genet. 2000. PMID: 11092758

6

Heteroplasmic segregation associated with trisomy-9 in cultured human cells.

Lehtinen SK, Spelbrink JN, Jacobs HT. Lehtinen SK, et al. Among authors: spelbrink jn. Somat Cell Mol Genet. 1999 Nov;25(5-6):263-74. doi: 10.1023/a:1019960230827. Somat Cell Mol Genet. 1999. PMID: 15328906

7

The dangers of extended PCR in the clinic.

Kajander OA, Poulton J, Spelbrink JN, Rovio A, Karhunen PJ, Jacobs HT. Kajander OA, et al. Among authors: spelbrink jn. Nat Med. 1999 Sep;5(9):965-6. doi: 10.1038/12379. Nat Med. 1999. PMID: 10470052 No abstract available.

8

The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover.

Toompuu M, Yasukawa T, Suzuki T, Hakkinen T, Spelbrink JN, Watanabe K, Jacobs HT. Toompuu M, et al. Among authors: spelbrink jn. J Biol Chem. 2002 Jun 21;277(25):22240-50. doi: 10.1074/jbc.M200338200. Epub 2002 Mar 27. J Biol Chem. 2002. PMID: 11919191 Free article.

9

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.

Pohjoismäki JL, Wanrooij S, Hyvärinen AK, Goffart S, Holt IJ, Spelbrink JN, Jacobs HT. Pohjoismäki JL, et al. Among authors: spelbrink jn. Nucleic Acids Res. 2006;34(20):5815-28. doi: 10.1093/nar/gkl703. Epub 2006 Oct 24. Nucleic Acids Res. 2006. PMID: 17062618 Free PMC article.

10

Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.

Tyynismaa H, Mjosund KP, Wanrooij S, Lappalainen I, Ylikallio E, Jalanko A, Spelbrink JN, Paetau A, Suomalainen A. Tyynismaa H, et al. Among authors: spelbrink jn. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17687-92. doi: 10.1073/pnas.0505551102. Epub 2005 Nov 21. Proc Natl Acad Sci U S A. 2005. PMID: 16301523 Free PMC article.

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