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Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis.
Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, Khosla S. Hofbauer LC, et al. Among authors: spelsberg tc. Endocrinology. 1999 Oct;140(10):4382-9. doi: 10.1210/endo.140.10.7034. Endocrinology. 1999. PMID: 10499489
Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2.
Mödder UI, Monroe DG, Fraser DG, Spelsberg TC, Rosen CJ, Géhin M, Chambon P, O'Malley BW, Khosla S. Mödder UI, et al. Among authors: spelsberg tc. J Biol Chem. 2009 Jul 10;284(28):18767-77. doi: 10.1074/jbc.M109.000836. Epub 2009 May 7. J Biol Chem. 2009. PMID: 19423703 Free PMC article.
Evidence of steroid receptors in human osteoblast-like cells.
Colvard D, Spelsberg T, Eriksen E, Keeting P, Riggs BL. Colvard D, et al. Among authors: spelsberg t. Connect Tissue Res. 1989;20(1-4):33-40. doi: 10.3109/03008208909023872. Connect Tissue Res. 1989. PMID: 2612163
Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.
Oursler MJ, Pederson L, Fitzpatrick L, Riggs BL, Spelsberg T. Oursler MJ, et al. Among authors: spelsberg t. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5227-31. doi: 10.1073/pnas.91.12.5227. Proc Natl Acad Sci U S A. 1994. PMID: 8202473 Free PMC article.
Dose-response of estrogen on bone versus the uterus in ovariectomized mice.
Modder UI, Riggs BL, Spelsberg TC, Fraser DG, Atkinson EJ, Arnold R, Khosla S. Modder UI, et al. Among authors: spelsberg tc. Eur J Endocrinol. 2004 Oct;151(4):503-10. doi: 10.1530/eje.0.1510503. Eur J Endocrinol. 2004. PMID: 15476452
2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells.
Benedikt MB, Mahlum EW, Shogren KL, Subramaniam M, Spelsberg TC, Yaszemski MJ, Maran A. Benedikt MB, et al. Among authors: spelsberg tc. J Cell Biochem. 2010 Apr 1;109(5):950-6. doi: 10.1002/jcb.22473. J Cell Biochem. 2010. PMID: 20082321
Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice.
Mödder UI, Sanyal A, Kearns AE, Sibonga JD, Nishihara E, Xu J, O'Malley BW, Ritman EL, Riggs BL, Spelsberg TC, Khosla S. Mödder UI, et al. Among authors: spelsberg tc. Endocrinology. 2004 Feb;145(2):913-21. doi: 10.1210/en.2003-1089. Epub 2003 Oct 16. Endocrinology. 2004. PMID: 14563705
17beta-estradiol-dependent activation of signal transducer and activator of transcription-1 in human fetal osteoblasts is dependent on Src kinase activity.
Kennedy AM, Shogren KL, Zhang M, Turner RT, Spelsberg TC, Maran A. Kennedy AM, et al. Among authors: spelsberg tc. Endocrinology. 2005 Jan;146(1):201-7. doi: 10.1210/en.2004-0486. Epub 2004 Oct 7. Endocrinology. 2005. PMID: 15471961
Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens.
Hawse JR, Subramaniam M, Cicek M, Wu X, Gingery A, Grygo SB, Sun Z, Pitel KS, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC. Hawse JR, et al. Among authors: spelsberg tc. PLoS One. 2013;8(1):e54613. doi: 10.1371/journal.pone.0054613. Epub 2013 Jan 28. PLoS One. 2013. PMID: 23382923 Free PMC article.
TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts.
Hawse JR, Cicek M, Grygo SB, Bruinsma ES, Rajamannan NM, van Wijnen AJ, Lian JB, Stein GS, Oursler MJ, Subramaniam M, Spelsberg TC. Hawse JR, et al. Among authors: spelsberg tc. PLoS One. 2011 Apr 29;6(4):e19429. doi: 10.1371/journal.pone.0019429. PLoS One. 2011. PMID: 21559363 Free PMC article.
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