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Clozapine: more than 900 mg/day may be needed.
Maccall C, Billcliff N, Igbrude W, Natynczuk S, Spencer EP, Flanagan RJ. Maccall C, et al. Among authors: spencer ep. J Psychopharmacol. 2009 Mar;23(2):206-10. doi: 10.1177/0269881108089819. Epub 2008 May 30. J Psychopharmacol. 2009. PMID: 18515467
Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography.
Voineskos AN, Wilson AA, Boovariwala A, Sagrati S, Houle S, Rusjan P, Sokolov S, Spencer EP, Ginovart N, Meyer JH. Voineskos AN, et al. Among authors: spencer ep. Psychopharmacology (Berl). 2007 Sep;193(4):539-45. doi: 10.1007/s00213-007-0806-z. Epub 2007 May 12. Psychopharmacology (Berl). 2007. PMID: 17497139 Clinical Trial.
CYP2C19 genotype predicts steady state escitalopram concentration in GENDEP.
Huezo-Diaz P, Perroud N, Spencer EP, Smith R, Sim S, Virding S, Uher R, Gunasinghe C, Gray J, Campbell D, Hauser J, Maier W, Marusic A, Rietschel M, Perez J, Giovannini C, Mors O, Mendlewicz J, McGuffin P, Farmer AE, Ingelman-Sundberg M, Craig IW, Aitchison KJ. Huezo-Diaz P, et al. Among authors: spencer ep. J Psychopharmacol. 2012 Mar;26(3):398-407. doi: 10.1177/0269881111414451. Epub 2011 Sep 17. J Psychopharmacol. 2012. PMID: 21926427 Clinical Trial.
Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients.
Rostami-Hodjegan A, Amin AM, Spencer EP, Lennard MS, Tucker GT, Flanagan RJ. Rostami-Hodjegan A, et al. Among authors: spencer ep. J Clin Psychopharmacol. 2004 Feb;24(1):70-8. doi: 10.1097/01.jcp.0000106221.36344.4d. J Clin Psychopharmacol. 2004. PMID: 14709950
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