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Pendrin modulates ENaC function by changing luminal HCO3-.
Pech V, Pham TD, Hong S, Weinstein AM, Spencer KB, Duke BJ, Walp E, Kim YH, Sutliff RL, Bao HF, Eaton DC, Wall SM. Pech V, et al. Among authors: spencer kb. J Am Soc Nephrol. 2010 Nov;21(11):1928-41. doi: 10.1681/ASN.2009121257. Epub 2010 Oct 21. J Am Soc Nephrol. 2010. PMID: 20966128 Free PMC article.
Targeting Xist with compounds that disrupt RNA structure and X inactivation.
Aguilar R, Spencer KB, Kesner B, Rizvi NF, Badmalia MD, Mrozowich T, Mortison JD, Rivera C, Smith GF, Burchard J, Dandliker PJ, Patel TR, Nickbarg EB, Lee JT. Aguilar R, et al. Among authors: spencer kb. Nature. 2022 Apr;604(7904):160-166. doi: 10.1038/s41586-022-04537-z. Epub 2022 Mar 30. Nature. 2022. PMID: 35355011
Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
Michaelian N, Sadybekov A, Besserer-Offroy É, Han GW, Krishnamurthy H, Zamlynny BA, Fradera X, Siliphaivanh P, Presland J, Spencer KB, Soisson SM, Popov P, Sarret P, Katritch V, Cherezov V. Michaelian N, et al. Among authors: spencer kb. Nat Commun. 2021 May 20;12(1):2971. doi: 10.1038/s41467-021-23149-1. Nat Commun. 2021. PMID: 34016973 Free PMC article.
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
Katz JD, Jewell JP, Guerin DJ, Lim J, Dinsmore CJ, Deshmukh SV, Pan BS, Marshall CG, Lu W, Altman MD, Dahlberg WK, Davis L, Falcone D, Gabarda AE, Hang G, Hatch H, Holmes R, Kunii K, Lumb KJ, Lutterbach B, Mathvink R, Nazef N, Patel SB, Qu X, Reilly JF, Rickert KW, Rosenstein C, Soisson SM, Spencer KB, Szewczak AA, Walker D, Wang W, Young J, Zeng Q. Katz JD, et al. Among authors: spencer kb. J Med Chem. 2011 Jun 23;54(12):4092-108. doi: 10.1021/jm200112k. Epub 2011 May 24. J Med Chem. 2011. PMID: 21608528
14 results