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Non-syndromic monogenic male infertility.
Guerri G, Maniscalchi T, Barati S, Busetto GM, Del Giudice F, De Berardinis E, Cannarella R, Calogero AE, Bertelli M. Guerri G, et al. Acta Biomed. 2019 Sep 30;90(10-S):62-67. doi: 10.23750/abm.v90i10-S.8762. Acta Biomed. 2019. PMID: 31577257 Free PMC article. Review.
Infertility is a widespread clinical problem affecting 8-12% of couples worldwide. Of these, about 30% are diagnosed with idiopathic infertility since no causative factor is found. ...Mutations of specific genes involved in meiosis, mitosis or spermiohistogenesis result in …
Infertility is a widespread clinical problem affecting 8-12% of couples worldwide. Of these, about 30% are diagnosed with idiopathic …
Klinefelter syndrome and TESE-ICSI.
Plotton I, Brosse A, Cuzin B, Lejeune H. Plotton I, et al. Ann Endocrinol (Paris). 2014 May;75(2):118-25. doi: 10.1016/j.ando.2014.04.004. Epub 2014 Apr 29. Ann Endocrinol (Paris). 2014. PMID: 24786702 Review.
We will discuss first the potential fertility following Testicular Sperm Injection, then the physiopathology of spermatogenic failure and the origin of focal spermatogenesis and risk of aneuploidy in offspring, and third the advantage of searching spermatozoa earlie …
We will discuss first the potential fertility following Testicular Sperm Injection, then the physiopathology of spermatogenic fail …
Y chromosome polymorphisms in medicine.
Krausz C, Quintana-Murci L, Forti G. Krausz C, et al. Ann Med. 2004;36(8):573-83. doi: 10.1080/07853890410018853. Ann Med. 2004. PMID: 15768829 Review.
Recently, Y chromosomal polymorphisms have been applied in molecular medicine from the perspective of male-specific (spermatogenic failure, testis and prostate cancer) and prevalently male-associated (hypertension, autism) diseases. ...
Recently, Y chromosomal polymorphisms have been applied in molecular medicine from the perspective of male-specific (spermatogenic …
Microdissection testicular sperm extraction (micro-TESE) in men with infertility due to nonobstructive azoospermia: summary of current literature.
Achermann APP, Pereira TA, Esteves SC. Achermann APP, et al. Int Urol Nephrol. 2021 Nov;53(11):2193-2210. doi: 10.1007/s11255-021-02979-4. Epub 2021 Aug 19. Int Urol Nephrol. 2021. PMID: 34410586 Review.
However, geographic locations of testicular sperm producing-areas are uncertain, making microsurgical-guided sperm retrieval (microdissection testicular sperm extraction; micro-TESE) an attractive method to identify and retrieve sperm in patients with NOA due to spermatogenic …
However, geographic locations of testicular sperm producing-areas are uncertain, making microsurgical-guided sperm retrieval (microdissectio …
Gonadotropin-regulated testicular helicase (GRTH/DDX25): an essential regulator of spermatogenesis.
Dufau ML, Tsai-Morris CH. Dufau ML, et al. Trends Endocrinol Metab. 2007 Oct;18(8):314-20. doi: 10.1016/j.tem.2007.09.001. Epub 2007 Sep 21. Trends Endocrinol Metab. 2007. PMID: 17889551 Review.
Gonadotropin-regulated testicular helicase (GRTH/DDX25), a target of gonadotropin and androgen action, is a post-transcriptional regulator of key spermatogenesis genes. Male mice lacking GRTH are sterile, with spermatogenic arrest owing to the failure of round sperm …
Gonadotropin-regulated testicular helicase (GRTH/DDX25), a target of gonadotropin and androgen action, is a post-transcriptional regulator o …
[Genetic aspects of male infertility].
Guichaoua MR, Luciani JM. Guichaoua MR, et al. Rev Prat. 1993 Apr 15;43(8):960-4. Rev Prat. 1993. PMID: 8341978 Review. French.
Specific alteration of genes controlling spermatogenesis is excluded because all chromosomes are involved in the anomaly and breakpoints are distributed at random. In the aim to explain the spermatogenic failure, three mechanisms are proposed: X-autosome interaction …
Specific alteration of genes controlling spermatogenesis is excluded because all chromosomes are involved in the anomaly and breakpoints are …