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Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.
Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH. Dusaban SS, et al. J Neuroinflammation. 2017 Jun 2;14(1):111. doi: 10.1186/s12974-017-0882-x. J Neuroinflammation. 2017. PMID: 28577576 Free PMC article.
BACKGROUND: Sphingosine 1-phosphate (S1P) signals through G protein-coupled receptors to elicit a wide range of cellular responses. ...S1P(3) is most highly expressed and upregulated on astrocytes, however, thus we explored the involvemen …
BACKGROUND: Sphingosine 1-phosphate (S1P) signals through G protein-coupled receptors to elicit a wide ra …
Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.
Miguez A, García-Díaz Barriga G, Brito V, Straccia M, Giralt A, Ginés S, Canals JM, Alberch J. Miguez A, et al. Hum Mol Genet. 2015 Sep 1;24(17):4958-70. doi: 10.1093/hmg/ddv218. Epub 2015 Jun 10. Hum Mol Genet. 2015. PMID: 26063761
Synaptic and memory dysfunction in HD mouse models have been related to low levels of brain-derived neurotrophic factor (BDNF) and imbalance between TrkB and p75(NTR) receptors. In addition, astrocyte over-activation has also been suggested to contribute to HD cogni …
Synaptic and memory dysfunction in HD mouse models have been related to low levels of brain-derived neurotrophic factor (BDNF) and imbalance …