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Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor.
Kleuser B, Maceyka M, Milstien S, Spiegel S. Kleuser B, et al. Among authors: spiegel s. FEBS Lett. 2001 Aug 10;503(1):85-90. doi: 10.1016/s0014-5793(01)02697-7. FEBS Lett. 2001. PMID: 11513860
Platelet-derived growth factor, in addition to rapidly stimulating cytosolic sphingosine kinase, also induced a large increase in nucleoplasm-associated activity after 12-24 h that correlated with progression of cells to the S-phase of the cell cycle and translocation of s …
Platelet-derived growth factor, in addition to rapidly stimulating cytosolic sphingosine kinase, also induced a large increase in nucleoplas …
Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.
Desai NN, Zhang H, Olivera A, Mattie ME, Spiegel S. Desai NN, et al. Among authors: spiegel s. J Biol Chem. 1992 Nov 15;267(32):23122-8. J Biol Chem. 1992. PMID: 1429659
., and Spiegel, S. (1991) J. Cell Biol. 114, 155-167). The present study demonstrates that mitogenic concentrations of sphingosine induce early increases in sphingosine-1-phosphate levels which precede the increase in the potent mitogen, phosphatidic acid. ...
., and Spiegel, S. (1991) J. Cell Biol. 114, 155-167). The present study demonstrates that mitogenic concentrations of sphingo …
Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.
Olivera A, Buckley NE, Spiegel S. Olivera A, et al. Among authors: spiegel s. J Biol Chem. 1992 Dec 25;267(36):26121-7. J Biol Chem. 1992. PMID: 1464623
Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates growth and differentiation of neuroblastoma N18 cells.
Masco D, Van de Walle M, Spiegel S. Masco D, et al. Among authors: spiegel s. J Neurosci. 1991 Aug;11(8):2443-52. doi: 10.1523/JNEUROSCI.11-08-02443.1991. J Neurosci. 1991. PMID: 1651376 Free PMC article.
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines.
Desai NN, Spiegel S. Desai NN, et al. Among authors: spiegel s. Biochem Biophys Res Commun. 1991 Nov 27;181(1):361-6. doi: 10.1016/s0006-291x(05)81427-5. Biochem Biophys Res Commun. 1991. PMID: 1958205
Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.
Zhang H, Desai NN, Olivera A, Seki T, Brooker G, Spiegel S. Zhang H, et al. Among authors: spiegel s. J Cell Biol. 1991 Jul;114(1):155-67. doi: 10.1083/jcb.114.1.155. J Cell Biol. 1991. PMID: 2050740 Free PMC article.
Gibson. and S. Spiegel. 1990. J. Biol. Chem. 265:76-81). The present study provides new insights into the formation and function of a unique phospholipid, a metabolite of sphingosine, which was unequivocally identified as sphingosine-1-phosphate. ...
Gibson. and S. Spiegel. 1990. J. Biol. Chem. 265:76-81). The present study provides new insights into the formation and functi …
Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.
Zhang H, Desai NN, Murphey JM, Spiegel S. Zhang H, et al. Among authors: spiegel s. J Biol Chem. 1990 Dec 5;265(34):21309-16. J Biol Chem. 1990. PMID: 2250025
., and Spiegel, S. (1990) J. Biol. Chem. 265, 76-81). The present study demonstrates that mitogenic concentrations of sphingosine induce early increases in cytosolic phosphatidic acid, which is a potent mitogen for Swiss 3T3 cells. ...
., and Spiegel, S. (1990) J. Biol. Chem. 265, 76-81). The present study demonstrates that mitogenic concentrations of sphingos …
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
Zhang H, Buckley NE, Gibson K, Spiegel S. Zhang H, et al. Among authors: spiegel s. J Biol Chem. 1990 Jan 5;265(1):76-81. J Biol Chem. 1990. PMID: 2294122
The bimodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1.
Buckley NE, Matyas GR, Spiegel S. Buckley NE, et al. Among authors: spiegel s. Exp Cell Res. 1990 Jul;189(1):13-21. doi: 10.1016/0014-4827(90)90250-e. Exp Cell Res. 1990. PMID: 2347373
Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.
Spiegel S. Spiegel S. J Biol Chem. 1989 Apr 25;264(12):6766-72. J Biol Chem. 1989. PMID: 2496120
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