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Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an EULAR task force.
Strehl C, Bijlsma JW, de Wit M, Boers M, Caeyers N, Cutolo M, Dasgupta B, Dixon WG, Geenen R, Huizinga TW, Kent A, de Thurah AL, Listing J, Mariette X, Ray DW, Scherer HU, Seror R, Spies CM, Tarp S, Wiek D, Winthrop KL, Buttgereit F. Strehl C, et al. Among authors: spies cm. Ann Rheum Dis. 2016 Jun;75(6):952-7. doi: 10.1136/annrheumdis-2015-208916. Epub 2016 Mar 1. Ann Rheum Dis. 2016. PMID: 26933146 Review.
Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis.
Bartholome B, Spies CM, Gaber T, Schuchmann S, Berki T, Kunkel D, Bienert M, Radbruch A, Burmester GR, Lauster R, Scheffold A, Buttgereit F. Bartholome B, et al. Among authors: spies cm. FASEB J. 2004 Jan;18(1):70-80. doi: 10.1096/fj.03-0328com. FASEB J. 2004. PMID: 14718388
Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway.
Spies CM, Schaumann DH, Berki T, Mayer K, Jakstadt M, Huscher D, Wunder C, Burmester GR, Radbruch A, Lauster R, Scheffold A, Buttgereit F. Spies CM, et al. Ann Rheum Dis. 2006 Sep;65(9):1139-46. doi: 10.1136/ard.2005.048272. Epub 2006 Jan 31. Ann Rheum Dis. 2006. PMID: 16449313 Free PMC article.
Pharmacology of glucocorticoids in rheumatoid arthritis.
Spies CM, Bijlsma JW, Burmester GR, Buttgereit F. Spies CM, et al. Curr Opin Pharmacol. 2010 Jun;10(3):302-7. doi: 10.1016/j.coph.2010.02.001. Epub 2010 Mar 2. Curr Opin Pharmacol. 2010. PMID: 20202903 Review.
Origin and functional activity of the membrane-bound glucocorticoid receptor.
Strehl C, Gaber T, Löwenberg M, Hommes DW, Verhaar AP, Schellmann S, Hahne M, Fangradt M, Wagegg M, Hoff P, Scheffold A, Spies CM, Burmester GR, Buttgereit F. Strehl C, et al. Among authors: spies cm. Arthritis Rheum. 2011 Dec;63(12):3779-88. doi: 10.1002/art.30637. Arthritis Rheum. 2011. PMID: 21898343 Free article.
28 results