Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

320 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.
Groh V, Wu J, Yee C, Spies T. Groh V, et al. Among authors: spies t. Nature. 2002 Oct 17;419(6908):734-8. doi: 10.1038/nature01112. Nature. 2002. PMID: 12384702
In humans, NKG2D is expressed on most natural killer cells, gammadelta T cells and CD8alphabeta T cells. Ligands of NKG2D include the major histocompatibility complex class I homologues MICA and MICB, which function as signals of cellular stress. ...This mode of …
In humans, NKG2D is expressed on most natural killer cells, gammadelta T cells and CD8alphabeta T cells. Ligands of NKG2D incl …
Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus.
Dai Z, Turtle CJ, Booth GC, Riddell SR, Gooley TA, Stevens AM, Spies T, Groh V. Dai Z, et al. Among authors: spies t. J Exp Med. 2009 Apr 13;206(4):793-805. doi: 10.1084/jem.20081648. Epub 2009 Mar 16. J Exp Med. 2009. PMID: 19289577 Free PMC article.
The NKG2D(+)CD4(+) T cells correspond to a normally occurring small CD4 T cell subset that is autoreactive, primed to produce IL-10, and clearly distinct from proinflammatory and cytolytic CD4 T cells with cytokine-induced NKG2D expression that occur in rheum …
The NKG2D(+)CD4(+) T cells correspond to a normally occurring small CD4 T cell subset that is autoreactive, primed to produce …
Regulation of NKG2D ligands: a purposeful but delicate affair.
Spies T. Spies T. Nat Immunol. 2008 Sep;9(9):1013-5. doi: 10.1038/ni0908-1013. Nat Immunol. 2008. PMID: 18711442 No abstract available.
Natural cytotoxicity receptors: influenza virus in the spotlight.
Spies T, Groh V. Spies T, et al. Nat Immunol. 2006 May;7(5):443-4. doi: 10.1038/ni0506-443. Nat Immunol. 2006. PMID: 16622429 No abstract available.
Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity.
Groh V, Smythe K, Dai Z, Spies T. Groh V, et al. Among authors: spies t. Nat Immunol. 2006 Jul;7(7):755-62. doi: 10.1038/ni1350. Epub 2006 May 28. Nat Immunol. 2006. PMID: 16732291
Tumor-associated ligands of the activating NKG2D receptor can effectively stimulate T cell responses at early but not late stages of tumor growth. ...In contrast, FasL suppressed proliferation of T cells in vitro that did not receive NKG2D costimulation. Similar obs …
Tumor-associated ligands of the activating NKG2D receptor can effectively stimulate T cell responses at early but not late stages of …
Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B.
McSharry BP, Burgert HG, Owen DP, Stanton RJ, Prod'homme V, Sester M, Koebernick K, Groh V, Spies T, Cox S, Little AM, Wang EC, Tomasec P, Wilkinson GW. McSharry BP, et al. Among authors: spies t. J Virol. 2008 May;82(9):4585-94. doi: 10.1128/JVI.02251-07. Epub 2008 Feb 20. J Virol. 2008. PMID: 18287244 Free PMC article.
Indeed, the capacity of E3/19K to inhibit transport of HLA class I (HLA-I) to the cell surface, thereby preventing peptide presentation to CD8(+) T cells, has long been recognized as a paradigm for viral immune evasion. ...Thus, E3/19K has a dual function: inhibition of …
Indeed, the capacity of E3/19K to inhibit transport of HLA class I (HLA-I) to the cell surface, thereby preventing peptide presentation to C …
Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis.
Capraru D, Müller A, Csernok E, Gross WL, Holl-Ulrich K, Northfield J, Klenerman P, Herlyn K, Holle J, Gottschlich S, Voswinkel J, Spies T, Fagin U, Jabs WJ, Lamprecht P. Capraru D, et al. Among authors: spies t. Clin Immunol. 2008 May;127(2):144-50. doi: 10.1016/j.clim.2007.12.004. Epub 2008 Mar 4. Clin Immunol. 2008. PMID: 18313361
Expansion of circulating CD28- T-cells reminiscent of effector memory T-cells (T(EM)) has been reported in Wegener's granulomatosis (WG) recently. To investigate the role of T(EM) in WG, we analyzed the expression of the activating NK-receptor NKG2D an …
Expansion of circulating CD28- T-cells reminiscent of effector memory T-cells (T(EM)) has been reported in Wegener's gr …
HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells.
Carbone E, Neri P, Mesuraca M, Fulciniti MT, Otsuki T, Pende D, Groh V, Spies T, Pollio G, Cosman D, Catalano L, Tassone P, Rotoli B, Venuta S. Carbone E, et al. Among authors: spies t. Blood. 2005 Jan 1;105(1):251-8. doi: 10.1182/blood-2004-04-1422. Epub 2004 Aug 24. Blood. 2005. PMID: 15328155
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.
Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier LL, Groh V, Spies T, Ebert EC, Green PH, Jabri B. Meresse B, et al. Among authors: spies t. Immunity. 2004 Sep;21(3):357-66. doi: 10.1016/j.immuni.2004.06.020. Immunity. 2004. PMID: 15357947
Here, we show that, under conditions of dysregulated IL15 expression in vivo in patients with celiac disease and in vitro in healthy individuals, multiple steps of the NKG2D/DAP10 signaling pathway leading to ERK and JNK activation are coordinately primed to activate direct cytol …
Here, we show that, under conditions of dysregulated IL15 expression in vivo in patients with celiac disease and in vitro in healthy individ …
Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo.
Wiemann K, Mittrücker HW, Feger U, Welte SA, Yokoyama WM, Spies T, Rammensee HG, Steinle A. Wiemann K, et al. Among authors: spies t. J Immunol. 2005 Jul 15;175(2):720-9. doi: 10.4049/jimmunol.175.2.720. J Immunol. 2005. PMID: 16002667
This deficiency concurs with a pronounced down-regulation of surface NKG2D that is also seen on activated CD8 T cells. As a consequence, H2-K(b)-MICA mice fail to reject MICA-expressing tumors and to mount normal CD8 T cell responses upon Listeria infection emphasiz …
This deficiency concurs with a pronounced down-regulation of surface NKG2D that is also seen on activated CD8 T cells. As a consequen …
320 results
Jump to page
Feedback