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Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio.
Goyens PL, Spilker ME, Zock PL, Katan MB, Mensink RP. Goyens PL, et al. Am J Clin Nutr. 2006 Jul;84(1):44-53. doi: 10.1093/ajcn/84.1.44. Am J Clin Nutr. 2006. PMID: 16825680 Clinical Trial.
A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor.
Chen W, Boras B, Sung T, Yu Y, Zheng J, Wang D, Hu W, Spilker ME, D'Argenio DZ. Chen W, et al. Among authors: spilker me. J Pharmacokinet Pharmacodyn. 2020 Apr;47(2):163-182. doi: 10.1007/s10928-020-09680-6. Epub 2020 Mar 11. J Pharmacokinet Pharmacodyn. 2020. PMID: 32162138
A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships.
Guerrero YA, Desai D, Sullivan C, Kindt E, Spilker ME, Maurer TS, Solomon DE, Bartlett DW. Guerrero YA, et al. Among authors: spilker me. AAPS J. 2020 Mar 2;22(2):53. doi: 10.1208/s12248-020-0430-y. AAPS J. 2020. PMID: 32124093
Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.
Bradshaw EL, Spilker ME, Zang R, Bansal L, He H, Jones RDO, Le K, Penney M, Schuck E, Topp B, Tsai A, Xu C, Nijsen MJMA, Chan JR. Bradshaw EL, et al. Among authors: spilker me. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):777-791. doi: 10.1002/psp4.12463. Epub 2019 Oct 25. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31535440 Free PMC article.
Metabolomics activity screening for identifying metabolites that modulate phenotype.
Guijas C, Montenegro-Burke JR, Warth B, Spilker ME, Siuzdak G. Guijas C, et al. Among authors: spilker me. Nat Biotechnol. 2018 Apr 5;36(4):316-320. doi: 10.1038/nbt.4101. Nat Biotechnol. 2018. PMID: 29621222 Free PMC article.
METLIN: A Technology Platform for Identifying Knowns and Unknowns.
Guijas C, Montenegro-Burke JR, Domingo-Almenara X, Palermo A, Warth B, Hermann G, Koellensperger G, Huan T, Uritboonthai W, Aisporna AE, Wolan DW, Spilker ME, Benton HP, Siuzdak G. Guijas C, et al. Among authors: spilker me. Anal Chem. 2018 Mar 6;90(5):3156-3164. doi: 10.1021/acs.analchem.7b04424. Epub 2018 Feb 9. Anal Chem. 2018. PMID: 29381867 Free PMC article.
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
Nijsen MJMA, Wu F, Bansal L, Bradshaw-Pierce E, Chan JR, Liederer BM, Mettetal JT, Schroeder P, Schuck E, Tsai A, Xu C, Chimalakonda A, Le K, Penney M, Topp B, Yamada A, Spilker ME. Nijsen MJMA, et al. Among authors: spilker me. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):135-146. doi: 10.1002/psp4.12282. Epub 2018 Feb 1. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29349875 Free PMC article. Review.
A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies.
Liu SH, Gu Y, Pascual B, Yan Z, Hallin M, Zhang C, Fan C, Wang W, Lam J, Spilker ME, Yafawi R, Blasi E, Simmons B, Huser N, Ho WH, Lindquist K, Tran TT, Kudaravalli J, Ma JT, Jimenez G, Barman I, Brown C, Chin SM, Costa MJ, Shelton D, Smeal T, Fantin VR, Pernasetti F. Liu SH, et al. Among authors: spilker me. Blood Adv. 2017 Jun 21;1(15):1088-1100. doi: 10.1182/bloodadvances.2016003921. eCollection 2017 Jun 27. Blood Adv. 2017. PMID: 29296751 Free PMC article.
Assessment of near-infrared fluorophores to study the biodistribution and tumor targeting of an IL13 receptor α2 antibody by fluorescence molecular tomography.
Gupta P, Wentland JA, Leal M, Ma D, Roach R, Esparza A, King L, Spilker ME, Bagi C, Winkelmann CT, Giddabasappa A. Gupta P, et al. Among authors: spilker me. Oncotarget. 2017 Jul 26;8(34):57231-57245. doi: 10.18632/oncotarget.19569. eCollection 2017 Aug 22. Oncotarget. 2017. PMID: 28915667 Free PMC article.
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