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Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression.
Kaltenecker D, Themanns M, Mueller KM, Spirk K, Suske T, Merkel O, Kenner L, Luís A, Kozlov A, Haybaeck J, Müller M, Han X, Moriggl R. Kaltenecker D, et al. Among authors: spirk k. Cytokine. 2019 Dec;124:154569. doi: 10.1016/j.cyto.2018.10.010. Epub 2018 Oct 30. Cytokine. 2019. PMID: 30389231 Free article. Review.
Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.
Beghini M, Wagner T, Luca AC, Metz M, Kaltenecker D, Spirk K, Hackl MT, Haybaeck J, Moriggl R, Kautzky-Willer A, Scherer T, Fürnsinn C. Beghini M, et al. Among authors: spirk k. PLoS One. 2021 Nov 24;16(11):e0260501. doi: 10.1371/journal.pone.0260501. eCollection 2021. PLoS One. 2021. PMID: 34818373 Free PMC article.
Parathyroid hormone induces a browning program in human white adipocytes.
Hedesan OC, Fenzl A, Digruber A, Spirk K, Baumgartner-Parzer S, Bilban M, Kenner L, Vierhapper M, Elbe-Bürger A, Kiefer FW. Hedesan OC, et al. Among authors: spirk k. Int J Obes (Lond). 2019 Jun;43(6):1319-1324. doi: 10.1038/s41366-018-0266-z. Epub 2018 Dec 5. Int J Obes (Lond). 2019. PMID: 30518824 Free PMC article.
Identification of ALK in Thinness.
Orthofer M, Valsesia A, Mägi R, Wang QP, Kaczanowska J, Kozieradzki I, Leopoldi A, Cikes D, Zopf LM, Tretiakov EO, Demetz E, Hilbe R, Boehm A, Ticevic M, Nõukas M, Jais A, Spirk K, Clark T, Amann S, Lepamets M, Neumayr C, Arnold C, Dou Z, Kuhn V, Novatchkova M, Cronin SJF, Tietge UJF, Müller S, Pospisilik JA, Nagy V, Hui CC, Lazovic J, Esterbauer H, Hagelkruys A, Tancevski I, Kiefer FW, Harkany T, Haubensak W, Neely GG, Metspalu A, Hager J, Gheldof N, Penninger JM. Orthofer M, et al. Among authors: spirk k. Cell. 2020 Jun 11;181(6):1246-1262.e22. doi: 10.1016/j.cell.2020.04.034. Epub 2020 May 21. Cell. 2020. PMID: 32442405 Free article.
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
Suske T, Sorger H, Manhart G, Ruge F, Prutsch N, Zimmerman MW, Eder T, Abdallah DI, Maurer B, Wagner C, Schönefeldt S, Spirk K, Pichler A, Pemovska T, Schweicker C, Pölöske D, Hubanic E, Jungherz D, Müller TA, Aung MMK, Orlova A, Pham HTT, Zimmel K, Krausgruber T, Bock C, Müller M, Dahlhoff M, Boersma A, Rülicke T, Fleck R, de Araujo ED, Gunning PT, Aittokallio T, Mustjoki S, Sanda T, Hartmann S, Grebien F, Hoermann G, Haferlach T, Staber PB, Neubauer HA, Look AT, Herling M, Moriggl R. Suske T, et al. Among authors: spirk k. J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536. J Clin Invest. 2024. PMID: 38618957 Free PMC article.