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IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation.
De Falco F, Del Papa B, Baldoni S, Sabatini R, Falzetti F, Di Ianni M, Martelli MP, Mezzasoma F, Pelullo M, Marconi P, Sportoletti P, Screpanti I, Rosati E. De Falco F, et al. Among authors: Sportoletti P. Cell Death Dis. 2018 Nov 26;9(12):1160. doi: 10.1038/s41419-018-1185-6. Cell Death Dis. 2018. PMID: 30478302 Free PMC article.
BRAF mutations in hairy-cell leukemia.
Tiacci E, Trifonov V, Schiavoni G, Holmes A, Kern W, Martelli MP, Pucciarini A, Bigerna B, Pacini R, Wells VA, Sportoletti P, Pettirossi V, Mannucci R, Elliott O, Liso A, Ambrosetti A, Pulsoni A, Forconi F, Trentin L, Semenzato G, Inghirami G, Capponi M, Di Raimondo F, Patti C, Arcaini L, Musto P, Pileri S, Haferlach C, Schnittger S, Pizzolo G, Foà R, Farinelli L, Haferlach T, Pasqualucci L, Rabadan R, Falini B. Tiacci E, et al. N Engl J Med. 2011 Jun 16;364(24):2305-15. doi: 10.1056/NEJMoa1014209. Epub 2011 Jun 11. N Engl J Med. 2011. PMID: 21663470 Free PMC article.
How does the NPM1 mutant induce leukemia?
Sportoletti P. Sportoletti P. Pediatr Rep. 2011 Jun 22;3 Suppl 2(Suppl 2):e6. doi: 10.4081/pr.2011.s2.e6. Pediatr Rep. 2011. PMID: 22053282 Free PMC article.
Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction.
Del Papa B, Sportoletti P, Cecchini D, Rosati E, Balucani C, Baldoni S, Fettucciari K, Marconi P, Martelli MF, Falzetti F, Di Ianni M. Del Papa B, et al. Eur J Immunol. 2013 Jan;43(1):182-7. doi: 10.1002/eji.201242643. Epub 2012 Dec 5. Eur J Immunol. 2013. PMID: 23161436
A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia.
Sportoletti P, Baldoni S, Del Papa B, Aureli P, Dorillo E, Ruggeri L, Plebani S, Amico V, Di Tommaso A, Rosati E, Marconi P, Di Ianni M, Falzetti F. Sportoletti P, et al. Leukemia. 2014 Feb;28(2):436-9. doi: 10.1038/leu.2013.289. Epub 2013 Oct 9. Leukemia. 2014. PMID: 24177259 No abstract available.
Clinical-Grade-Expanded Regulatory T Cells Prevent Graft-versus-Host Disease While Allowing a Powerful T Cell-Dependent Graft-versus-Leukemia Effect in Murine Models.
Del Papa B, Ruggeri L, Urbani E, Baldoni S, Cecchini D, Zei T, Iacucci Ostini R, Crescenzi B, Carotti A, Pierini A, Sportoletti P, Di Bartolomeo P, Falzetti F, Mecucci C, Velardi A, Martelli MF, Di Ianni M. Del Papa B, et al. Biol Blood Marrow Transplant. 2017 Nov;23(11):1847-1851. doi: 10.1016/j.bbmt.2017.07.009. Epub 2017 Jul 17. Biol Blood Marrow Transplant. 2017. PMID: 28729148
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