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Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.

Tesmer JJ, Berman DM, Gilman AG, Sprang SR. Tesmer JJ, et al. Among authors: sprang sr. Cell. 1997 Apr 18;89(2):251-61. doi: 10.1016/s0092-8674(00)80204-4. Cell. 1997. PMID: 9108480

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Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.

Sprang SR. Sprang SR. Biopolymers. 2016 Aug;105(8):449-62. doi: 10.1002/bip.22836. Biopolymers. 2016. PMID: 26996924 Free PMC article. Review.

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Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.

Kant R, Zeng B, Thomas CJ, Bothner B, Sprang SR. Kant R, et al. Among authors: sprang sr. Elife. 2016 Dec 23;5:e19238. doi: 10.7554/eLife.19238. Elife. 2016. PMID: 28008853 Free PMC article.

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GEFs: master regulators of G-protein activation.

Sprang S. Sprang S. Trends Biochem Sci. 2001 Apr;26(4):266-7. doi: 10.1016/s0968-0004(01)01818-7. Trends Biochem Sci. 2001. PMID: 11295560 No abstract available.

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Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects.

Du X, Sprang SR. Du X, et al. Among authors: sprang sr. Biochemistry. 2009 Jun 2;48(21):4538-47. doi: 10.1021/bi802359b. Biochemistry. 2009. PMID: 19610677 Free PMC article.

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A method to determine 18 O kinetic isotope effects in the hydrolysis of nucleotide triphosphates.

Du X, Ferguson K, Gregory R, Sprang SR. Du X, et al. Among authors: sprang sr. Anal Biochem. 2008 Jan 15;372(2):213-21. doi: 10.1016/j.ab.2007.09.013. Epub 2007 Sep 14. Anal Biochem. 2008. PMID: 17963711 Free PMC article.

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Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.

Chen Z, Guo L, Sprang SR, Sternweis PC. Chen Z, et al. Among authors: sprang sr. Protein Sci. 2011 Jan;20(1):107-17. doi: 10.1002/pro.542. Protein Sci. 2011. PMID: 21064165 Free PMC article.

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Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain.

Chen Z, Guo L, Hadas J, Gutowski S, Sprang SR, Sternweis PC. Chen Z, et al. Among authors: sprang sr. J Biol Chem. 2012 Jul 20;287(30):25490-500. doi: 10.1074/jbc.M111.333716. Epub 2012 Jun 1. J Biol Chem. 2012. PMID: 22661716 Free PMC article.

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Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF.

Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR. Chen Z, et al. Among authors: sprang sr. Structure. 2008 Oct 8;16(10):1532-43. doi: 10.1016/j.str.2008.07.009. Structure. 2008. PMID: 18940608 Free PMC article.

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Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins.

Sprang SR, Chen Z, Du X. Sprang SR, et al. Adv Protein Chem. 2007;74:1-65. doi: 10.1016/S0065-3233(07)74001-9. Adv Protein Chem. 2007. PMID: 17854654 Review.

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