Spred is a Sprouty-related suppressor of Ras signalling.
Nature. 2001.
PMID: 11493923
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Spred is a Sprouty-related suppressor of Ras signalling.
Nature. 2001 Aug 9;412(6847):647-51. doi: 10.1038/35088082.
Nature. 2001.
PMID: 11493923
Cellular proliferation, and differentiation of cells in response to extracellular signals, are controlled by the signal transduction pathway of Ras, Raf and MAP (mitogen-activated protein) kinase. ...Spred may represent a class of proteins that …
Cellular proliferation, and differentiation of cells in response to extracellular signals, are controlled by the signal tra …
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions.
J Biol Chem. 2010 Nov 12;285(46):35374-85. doi: 10.1074/jbc.M110.148445. Epub 2010 Aug 24.
J Biol Chem. 2010.
PMID: 20736167
Free PMC article.
The mammalian SPRED (Sprouty-related protein with an EVH1 domain) proteins include a family of three members, SPRED1-3. Currently, little is known about their biochemistry. The best described, SPRED1, has been shown to inhibit the Ras/ERK pathway downs …
The mammalian SPRED (Sprouty-related protein with an EVH1 domain) proteins include a family of three members, SPRED1-3. …
Getting a first clue about SPRED functions.
Bioessays. 2007 Sep;29(9):897-907. doi: 10.1002/bies.20632.
Bioessays. 2007.
PMID: 17691106
Review.
Spreds form a new protein family with an N-terminal Enabled/VASP homology 1 domain (EVH1), a central c-Kit binding domain (KBD) and a C-terminal Sprouty-related domain (SPR). They are able to inhibit the Ras-ERK signalling pathway after various …
Spreds form a new protein family with an N-terminal Enabled/VASP homology 1 domain (EVH1), a central c-Kit binding domain (KBD) and a …
Role of endogenous inhibitors of cytokine signaling in allergic asthma.
Curr Med Chem. 2007;14(2):181-9. doi: 10.2174/092986707779313327.
Curr Med Chem. 2007.
PMID: 17266577
Review.
These cytokines regulate diverse biological functions by binding to receptors at the cell surface to activate complex signal transduction pathways, including the Janus kinase-signal transducer and activator of transcription (JAK-STAT) and the Ras-extra …
These cytokines regulate diverse biological functions by binding to receptors at the cell surface to activate complex signal trans …
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation.
J Biol Chem. 2001 Sep 28;276(39):36804-8. doi: 10.1074/jbc.C100386200. Epub 2001 Aug 8.
J Biol Chem. 2001.
PMID: 11495895
Free article.
Various mitogenic stimuli such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and phorbol 12,13-dibutyrate (PDBu) activate the Ras-Raf-MEK-ERK pathway, but the regulatory mechanism of this pathway remains to be investigated. ...These mutants reverted the …
Various mitogenic stimuli such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and phorbol 12,13-dibutyrate (PDBu) activat …
Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.
J Exp Med. 2005 Jan 3;201(1):73-82. doi: 10.1084/jem.20040616.
J Exp Med. 2005.
PMID: 15630138
Free PMC article.
T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play a critical role in allergic asthma. These cytokines transmit signals through the Janus kinase/signal transducer and activator of transcription (STAT) and the Ras-extracellular signal …
T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play a critical role in allergic asthma. These cytokines transmit si …
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