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Identification of orally available naphthyridine protein kinase D inhibitors.
Meredith EL, Ardayfio O, Beattie K, Dobler MR, Enyedy I, Gaul C, Hosagrahara V, Jewell C, Koch K, Lee W, Lehmann H, McKinsey TA, Miranda K, Pagratis N, Pancost M, Patnaik A, Phan D, Plato C, Qian M, Rajaraman V, Rao C, Rozhitskaya O, Ruppen T, Shi J, Siska SJ, Springer C, van Eis M, Vega RB, von Matt A, Yang L, Yoon T, Zhang JH, Zhu N, Monovich LG. Meredith EL, et al. J Med Chem. 2010 Aug 12;53(15):5400-21. doi: 10.1021/jm100075z. J Med Chem. 2010. PMID: 20684591
A cytotoxic agent can be generated selectively at cancer sites.
Bagshawe KD, Springer CJ, Searle F, Antoniw P, Sharma SK, Melton RG, Sherwood RF. Bagshawe KD, et al. Among authors: springer cj. Br J Cancer. 1988 Dec;58(6):700-3. doi: 10.1038/bjc.1988.293. Br J Cancer. 1988. PMID: 3265633 Free PMC article.
Antibody directed enzyme prodrug therapy (ADEPT): clinical report.
Bagshawe KD, Sharma SK, Springer CJ, Antoniw P, Boden JA, Rogers GT, Burke PJ, Melton RG, Sherwood RF. Bagshawe KD, et al. Among authors: springer cj. Dis Markers. 1991 May-Aug;9(3-4):233-8. Dis Markers. 1991. PMID: 1813213 Clinical Trial.
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