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Page 1
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons.
Al-Dalahmah O, Lam M, McInvale JJ, Qu W, Nguyen T, Mun JY, Kwon S, Ifediora N, Mahajan A, Humala N, Winters T, Angeles E, Jakubiak KA, Kühn R, Kim YA, De Rosa MC, Doege CA, Paryani F, Flowers X, Dovas A, Mela A, Lu H, DeTure MA, Vonsattel JP, Wszolek ZK, Dickson DW, Kuhlmann T, Zaehres H, Schöler HR, Sproul AA, Siegelin MD, De Jager PL, Goldman JE, Menon V, Canoll P, Hargus G. Al-Dalahmah O, et al. Among authors: sproul aa. Cell Stem Cell. 2024 May 2;31(5):676-693.e10. doi: 10.1016/j.stem.2024.03.013. Epub 2024 Apr 15. Cell Stem Cell. 2024. PMID: 38626772 Free PMC article.
Alzheimer's disease and the autophagic-lysosomal system.
Chung KM, Hernández N, Sproul AA, Yu WH. Chung KM, et al. Among authors: sproul aa. Neurosci Lett. 2019 Apr 1;697:49-58. doi: 10.1016/j.neulet.2018.05.017. Epub 2018 May 18. Neurosci Lett. 2019. PMID: 29758300 Review.
A proteogenomic tool uncovers protein markers for human microglial states.
Haage V, Bautista AR, Tuddenham J, Marshe V, Chiu R, Liu Y, Lama T, Kelly SS, Parghi NA, Park J, Buonfiglioli A, Furnari JL, Haq I, Pearse R, Patel R, Terzioglu G, Touil H, Zeng L, Noble J, Sarkis RA, Shneider NA, de Witte LD, Schneider J, Teich A, Young-Pearse TL, Riley C, Bennett DA, Canoll P, Bruce JN, Howden AJM, Lloyd AF, de Strooper B, Sher F, Sproul AA, Olah M, Taga M, Zhang Y, Caisheng L, Fujita M, Petyuk VA, De Jager PL. Haage V, et al. Among authors: sproul aa. bioRxiv [Preprint]. 2025 Apr 4:2025.03.31.646212. doi: 10.1101/2025.03.31.646212. bioRxiv. 2025. PMID: 40236015 Free PMC article. Preprint.
HDAC inhibitors engage MITF and the disease-associated microglia signature to enhance amyloid β uptake.
Haage V, Tuddenham JF, Bautista A, Garcia G F, White CC, Patel R, Comandante-Lou N, Marshe V, Griffin J, Zhou Y, Ghaffari D, Acheson B, Taga M, St George-Hyslop PH, Soni RK, Sims PA, Menon V, Sproul AA, De Jager PL. Haage V, et al. Among authors: sproul aa. Brain Behav Immun. 2025 Oct;129:279-293. doi: 10.1016/j.bbi.2025.05.027. Epub 2025 May 30. Brain Behav Immun. 2025. PMID: 40451396 Free PMC article.
Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics.
Bosc E, Anastasie J, Soualmia F, Coric P, Kim JY, Wang LQ, Lacin G, Zhao K, Patel R, Duplus E, Tixador P, Sproul AA, Brugg B, Reboud-Ravaux M, Troy CM, Shelanski ML, Bouaziz S, Karin M, El Amri C, Jacotot ED. Bosc E, et al. Among authors: sproul aa. Cell Death Dis. 2022 Nov 15;13(11):959. doi: 10.1038/s41419-022-05396-2. Cell Death Dis. 2022. PMID: 36379916 Free PMC article.
32 results