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Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel.
Palmer RK, Atwal K, Bakaj I, Carlucci-Derbyshire S, Buber MT, Cerne R, Cortés RY, Devantier HR, Jorgensen V, Pawlyk A, Lee SP, Sprous DG, Zhang Z, Bryant R. Palmer RK, et al. Among authors: Sprous DG. Assay Drug Dev Technol. 2010 Dec;8(6):703-13. doi: 10.1089/adt.2010.0334. Assay Drug Dev Technol. 2010. PMID: 21158685
Thymol and related alkyl phenols activate the hTRPA1 channel.
Lee SP, Buber MT, Yang Q, Cerne R, Cortés RY, Sprous DG, Bryant RW. Lee SP, et al. Among authors: Sprous DG. Br J Pharmacol. 2008 Apr;153(8):1739-49. doi: 10.1038/bjp.2008.85. Epub 2008 Mar 10. Br J Pharmacol. 2008. PMID: 18334983 Free PMC article.
Kinase inhibitor recognition by use of a multivariable QSAR model.
Sprous DG, Zhang J, Zhang L, Wang Z, Tepper MA. Sprous DG, et al. J Mol Graph Model. 2006 Jan;24(4):278-95. doi: 10.1016/j.jmgm.2005.09.004. Epub 2005 Oct 25. J Mol Graph Model. 2006. PMID: 16253531