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Copper & biological health.
Krupanidhi S, Sreekumar A, Sanjeevi CB. Krupanidhi S, et al. Indian J Med Res. 2008 Oct;128(4):448-61. Indian J Med Res. 2008. PMID: 19106440 Review.
Cu being a transition metal is ubiquitously engaged in biological systems to derive electrons through its participation in several enzymatic reactions. ...As a consequence, a wide variety of proteins viz., family of Cu bearing proteins, cuproenzymes, Cu trans …
Cu being a transition metal is ubiquitously engaged in biological systems to derive electrons through its participation in several en …
Structural insights into the interaction between molluscan hemocyanins and phenolic substrates: An in silico study using docking and molecular dynamics.
Naresh KN, Sreekumar A, Rajan SS. Naresh KN, et al. J Mol Graph Model. 2015 Sep;61:272-80. doi: 10.1016/j.jmgm.2015.07.006. Epub 2015 Jul 22. J Mol Graph Model. 2015. PMID: 26300244
Hemocyanin is a multimeric type-3 copper containing oxygen carrier protein that exhibits phenoloxidase-like activity and is found in selected species of arthropoda and mollusca. ...Here, using a combination of in silico molecular dynamics (MD) and docking studies on …
Hemocyanin is a multimeric type-3 copper containing oxygen carrier protein that exhibits phenoloxidase-like activity and is found in …
High throughput microscopy identifies bisphenol AP, a bisphenol A analog, as a novel AR down-regulator.
Stossi F, Dandekar RD, Bolt MJ, Newberg JY, Mancini MG, Kaushik AK, Putluri V, Sreekumar A, Mancini MA. Stossi F, et al. Oncotarget. 2016 Mar 29;7(13):16962-74. doi: 10.18632/oncotarget.7655. Oncotarget. 2016. PMID: 26918604 Free PMC article.
Prostate cancer remains a deadly disease especially when patients become resistant to drugs that target the Androgen Receptor (AR) ligand binding domain. ...Bisphenol AP (BPAP), which is used in chemical and medical industries, was identified as a down-regulator of …
Prostate cancer remains a deadly disease especially when patients become resistant to drugs that target the Androgen Receptor (AR) li …
Analysis of cerebrospinal fluid metabolites in patients with primary or metastatic central nervous system tumors.
Ballester LY, Lu G, Zorofchian S, Vantaku V, Putluri V, Yan Y, Arevalo O, Zhu P, Riascos RF, Sreekumar A, Esquenazi Y, Putluri N, Zhu JJ. Ballester LY, et al. Acta Neuropathol Commun. 2018 Aug 31;6(1):85. doi: 10.1186/s40478-018-0588-z. Acta Neuropathol Commun. 2018. PMID: 30170631 Free PMC article.
To test this hypothesis, we used mass spectrometry to analyze 129 distinct metabolites in CSF samples from patients without a history of cancer (n = 8) and with a variety of CNS tumor types (n = 23) (i.e., glioma IDH-mutant, glioma-IDH wildtype, metastatic lung canc …
To test this hypothesis, we used mass spectrometry to analyze 129 distinct metabolites in CSF samples from patients without a history …
Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism.
Yu W, Chen Y, Dubrulle J, Stossi F, Putluri V, Sreekumar A, Putluri N, Baluya D, Lai SY, Sandulache VC. Yu W, et al. Sci Rep. 2018 Mar 9;8(1):4306. doi: 10.1038/s41598-018-22640-y. Sci Rep. 2018. PMID: 29523854 Free PMC article.
DNA-bound cisplatin represents a small fraction of total intra-cellular cisplatin but generates a robust oxidative stress response. ...Oxidative stress is a critical component of cisplatin cytotoxicity in HNSCC and is reflected in acute changes in carbon flux …
DNA-bound cisplatin represents a small fraction of total intra-cellular cisplatin but generates a robust oxidative stress resp …
Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer.
Vantaku V, Dong J, Ambati CR, Perera D, Donepudi SR, Amara CS, Putluri V, Ravi SS, Robertson MJ, Piyarathna DWB, Villanueva M, von Rundstedt FC, Karanam B, Ballester LY, Terris MK, Bollag RJ, Lerner SP, Apolo AB, Villanueva H, Lee M, Sikora AG, Lotan Y, Sreekumar A, Coarfa C, Putluri N. Vantaku V, et al. Clin Cancer Res. 2019 Jun 15;25(12):3689-3701. doi: 10.1158/1078-0432.CCR-18-1515. Epub 2019 Mar 7. Clin Cancer Res. 2019. PMID: 30846479 Free PMC article.
Pathway analysis revealed a unique set of biochemical pathways that are highly deregulated in high-grade bladder cancer. Integromics analysis identified a molecular gene signature associated with poor patient survival in bladder cancer. ...CONCLUSIONS: Our study dem …
Pathway analysis revealed a unique set of biochemical pathways that are highly deregulated in high-grade bladder cancer. Integromics …
Unbiased Lipidomic Profiling of Triple-Negative Breast Cancer Tissues Reveals the Association of Sphingomyelin Levels with Patient Disease-Free Survival.
Purwaha P, Gu F, Piyarathna DWB, Rajendiran T, Ravindran A, Omilian AR, Jiralerspong S, Das G, Morrison C, Ambrosone C, Coarfa C, Putluri N, Sreekumar A. Purwaha P, et al. Metabolites. 2018 Jul 13;8(3):41. doi: 10.3390/metabo8030041. Metabolites. 2018. PMID: 30011843 Free PMC article.
The reprogramming of lipid metabolism is a hallmark of many cancers that has been shown to promote breast cancer progression. ...Our LC-MS lipidomics profiling of TNBC tumors has, for the first time, identified sphingomyelins as a potential prognostic marker and imp …
The reprogramming of lipid metabolism is a hallmark of many cancers that has been shown to promote breast cancer progression. ...Our …
Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells.
Shafi AA, Putluri V, Arnold JM, Tsouko E, Maity S, Roberts JM, Coarfa C, Frigo DE, Putluri N, Sreekumar A, Weigel NL. Shafi AA, et al. Oncotarget. 2015 Oct 13;6(31):31997-2012. doi: 10.18632/oncotarget.5585. Oncotarget. 2015. PMID: 26378018 Free PMC article.
Whether AR-V7 is simply a constitutively active substitute for AR or has novel gene targets that cause unique downstream changes is unresolved. ...Flux analyses indicate that the low citrate is a result of enhanced utilization rather than a failure to synthes …
Whether AR-V7 is simply a constitutively active substitute for AR or has novel gene targets that cause unique downstream changes is u …
Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance.
Putluri N, Maity S, Kommagani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, Nardone A, Fu X, Shaw C, Sarkar TR, Schiff R, Lydon JP, O'Malley BW, Ambs S, Das GM, Michailidis G, Sreekumar A. Putluri N, et al. Neoplasia. 2014 May;16(5):390-402. doi: 10.1016/j.neo.2014.05.007. Neoplasia. 2014. PMID: 25016594 Free PMC article.
Breast cancer (BCa) molecular subtypes include luminal A, luminal B, normal-like, HER-2-enriched, and basal-like tumors, among which luminal B and basal-like cancers are highly aggressive. ...Our study suggests for evaluating RRM2-associated metabolites as noninvasive mark …
Breast cancer (BCa) molecular subtypes include luminal A, luminal B, normal-like, HER-2-enriched, and basal-like tumors, among which …
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.
White MA, Tsouko E, Lin C, Rajapakshe K, Spencer JM, Wilkenfeld SR, Vakili SS, Pulliam TL, Awad D, Nikolos F, Katreddy RR, Kaipparettu BA, Sreekumar A, Zhang X, Cheung E, Coarfa C, Frigo DE. White MA, et al. Endocr Relat Cancer. 2018 Apr;25(4):453-469. doi: 10.1530/ERC-17-0051. Epub 2018 Feb 5. Endocr Relat Cancer. 2018. PMID: 29431615 Free PMC article.
Interestingly, GLUT12 trafficking to the plasma membrane was modulated by calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2)-5'-AMP-activated protein kinase (AMPK) signaling, a pathway we previously demonstrated to be a downstream effector of AR. Inhibiti …
Interestingly, GLUT12 trafficking to the plasma membrane was modulated by calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2)-5'-A …
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