Organocatalyzed stereospecific C-C bond formation of β-lactams

Sachin A Pawar; Saba Alapour; Sibusiso Khanyase; Zamani E D Cele; Srinivas Chitti; Hendrik G Kruger; Thavendran Govender; Per I Arvidsson

doi:10.1039/c3ob41858h

Organocatalyzed stereospecific C-C bond formation of β-lactams

Org Biomol Chem. 2013 Dec 28;11(48):8294-7. doi: 10.1039/c3ob41858h. Epub 2013 Nov 11.

Authors

Sachin A Pawar¹, Saba Alapour, Sibusiso Khanyase, Zamani E D Cele, Srinivas Chitti, Hendrik G Kruger, Thavendran Govender, Per I Arvidsson

Affiliation

¹ Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, South Africa. govenderthav@ukzn.ac.za.

PMID: 24217690
DOI: 10.1039/c3ob41858h

Abstract

Herein, we report the development of mild, organocatalyzed routes to novel carbapenam derivatives through aldol, Mannich and Michael C-C bond forming reactions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Catalysis
Stereoisomerism
beta-Lactams / chemical synthesis*
beta-Lactams / chemistry

Substances

Aldehydes
Anti-Bacterial Agents
beta-Lactams
3-hydroxybutanal