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G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets.
Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R. Insel PA, et al. Among authors: sriram k. Mol Pharmacol. 2015 Jul;88(1):181-7. doi: 10.1124/mol.115.098129. Epub 2015 Mar 3. Mol Pharmacol. 2015. PMID: 25737495 Free PMC article. Review.
Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation.
Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D. Jung G, et al. Among authors: sriram k. FASEB J. 2016 Apr;30(4):1464-79. doi: 10.1096/fj.15-280982. Epub 2015 Dec 16. FASEB J. 2016. PMID: 26675706 Free PMC article.
We propose that assessment of signaling be added to the indices of phenotypic maturation of hiPSC-CMs.-Jung, G., Fajardo, G., Ribeiro, A. J. S., Kooiker, K. B., Coronado, M., Zhao, M., Hu, D.-Q., Reddy, S., Kodo, K., Sriram, K., Insel, P. ...
We propose that assessment of signaling be added to the indices of phenotypic maturation of hiPSC-CMs.-Jung, G., Fajardo, G., Ribeiro, A. J. …
GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells.
Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA. Wiley SZ, et al. Among authors: sriram k. FASEB J. 2018 Mar;32(3):1170-1183. doi: 10.1096/fj.201700834R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29092903 Free PMC article.
CAF-expressed GPR68 is a mediator of low-pH-promoted regulation of the tumor microenvironments, in particular to PDAC cell-CAF interaction and may be a novel therapeutic target for pancreatic and perhaps other types of cancers.-Wiley, S. Z., Sriram, K., Liang, W., C …
CAF-expressed GPR68 is a mediator of low-pH-promoted regulation of the tumor microenvironments, in particular to PDAC cell-CAF interaction a …
GPR68: An Emerging Drug Target in Cancer.
Wiley SZ, Sriram K, Salmerón C, Insel PA. Wiley SZ, et al. Among authors: sriram k. Int J Mol Sci. 2019 Jan 28;20(3):559. doi: 10.3390/ijms20030559. Int J Mol Sci. 2019. PMID: 30696114 Free PMC article. Review.
GPCRomics: An Approach to Discover GPCR Drug Targets.
Insel PA, Sriram K, Gorr MW, Wiley SZ, Michkov A, Salmerón C, Chinn AM. Insel PA, et al. Among authors: sriram k. Trends Pharmacol Sci. 2019 Jun;40(6):378-387. doi: 10.1016/j.tips.2019.04.001. Epub 2019 May 8. Trends Pharmacol Sci. 2019. PMID: 31078319 Free PMC article. Review.
289 results