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Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.
Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S. Steele JW, et al. Mol Psychiatry. 2013 Aug;18(8):889-97. doi: 10.1038/mp.2012.106. Epub 2012 Jul 31. Mol Psychiatry. 2013. PMID: 22850627 Free PMC article.
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.
Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S. Audrain M, et al. Among authors: st george hyslop ph. Mol Psychiatry. 2019 Sep;24(9):1383-1397. doi: 10.1038/s41380-018-0258-3. Epub 2018 Oct 3. Mol Psychiatry. 2019. PMID: 30283031 Free PMC article.
Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Audrain M, Haure-Mirande JV, Mleczko J, Wang M, Griffin JK, St George-Hyslop PH, Fraser P, Zhang B, Gandy S, Ehrlich ME. Audrain M, et al. Among authors: st george hyslop ph. Alzheimers Dement. 2021 Feb;17(2):149-163. doi: 10.1002/alz.12256. Epub 2020 Dec 12. Alzheimers Dement. 2021. PMID: 33314529 Free PMC article.
Assembly of the presenilin γ-/ε-secretase complex.
St George-Hyslop P, Fraser PE. St George-Hyslop P, et al. J Neurochem. 2012 Jan;120 Suppl 1:84-88. doi: 10.1111/j.1471-4159.2011.07505.x. Epub 2011 Nov 28. J Neurochem. 2012. PMID: 22122073 Free article. Review.
390 results