St John SE - Search Results

1

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS).

St John SE, Tomar S, Stauffer SR, Mesecar AD. St John SE, et al. Bioorg Med Chem. 2015 Sep 1;23(17):6036-48. doi: 10.1016/j.bmc.2015.06.039. Epub 2015 Jun 19. Bioorg Med Chem. 2015. PMID: 26190463 Free PMC article.

2

Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2.

St John SE, Jensen KC, Kang S, Chen Y, Calamini B, Mesecar AD, Lipton MA. St John SE, et al. Bioorg Med Chem. 2013 Oct 1;21(19):6022-37. doi: 10.1016/j.bmc.2013.07.037. Epub 2013 Jul 27. Bioorg Med Chem. 2013. PMID: 23953689 Free PMC article.

3

Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance.

Deng X, StJohn SE, Osswald HL, O'Brien A, Banach BS, Sleeman K, Ghosh AK, Mesecar AD, Baker SC. Deng X, et al. J Virol. 2014 Oct;88(20):11886-98. doi: 10.1128/JVI.01528-14. Epub 2014 Aug 6. J Virol. 2014. PMID: 25100843 Free PMC article.

4

The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.

Báez-Santos YM, St John SE, Mesecar AD. Báez-Santos YM, et al. Among authors: st john se. Antiviral Res. 2015 Mar;115:21-38. doi: 10.1016/j.antiviral.2014.12.015. Epub 2014 Dec 29. Antiviral Res. 2015. PMID: 25554382 Free PMC article. Review.

5

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.

Tomar S, Johnston ML, St John SE, Osswald HL, Nyalapatla PR, Paul LN, Ghosh AK, Denison MR, Mesecar AD. Tomar S, et al. Among authors: st john se. J Biol Chem. 2015 Aug 7;290(32):19403-22. doi: 10.1074/jbc.M115.651463. Epub 2015 Jun 8. J Biol Chem. 2015. PMID: 26055715 Free PMC article.

6

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.

St John SE, Therkelsen MD, Nyalapatla PR, Osswald HL, Ghosh AK, Mesecar AD. St John SE, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5072-7. doi: 10.1016/j.bmcl.2015.10.023. Epub 2015 Oct 13. Bioorg Med Chem Lett. 2015. PMID: 26592814 Free PMC article.

7

X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus.

St John SE, Anson BJ, Mesecar AD. St John SE, et al. Sci Rep. 2016 May 13;6:25961. doi: 10.1038/srep25961. Sci Rep. 2016. PMID: 27173881 Free PMC article.

8

A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.

Deng X, Agnihothram S, Mielech AM, Nichols DB, Wilson MW, StJohn SE, Larsen SD, Mesecar AD, Lenschow DJ, Baric RS, Baker SC. Deng X, et al. J Virol. 2014 Oct;88(20):11825-33. doi: 10.1128/JVI.01749-14. Epub 2014 Aug 6. J Virol. 2014. PMID: 25100850 Free PMC article.

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