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Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitment.
Stack J, Hurst TP, Flannery SM, Brennan K, Rupp S, Oda SI, Khan AR, Bowie AG. Stack J, et al. J Biol Chem. 2013 Nov 22;288(47):33642-33653. doi: 10.1074/jbc.M113.485490. Epub 2013 Oct 10. J Biol Chem. 2013. PMID: 24114841 Free PMC article.
TRAM is required for TLR2 endosomal signaling to type I IFN induction.
Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG. Stack J, et al. J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10. J Immunol. 2014. PMID: 25385819 Free PMC article.
Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
DiPerna G, Stack J, Bowie AG, Boyd A, Kotwal G, Zhang Z, Arvikar S, Latz E, Fitzgerald KA, Marshall WL. DiPerna G, et al. Among authors: stack j. J Biol Chem. 2004 Aug 27;279(35):36570-8. doi: 10.1074/jbc.M400567200. Epub 2004 Jun 23. J Biol Chem. 2004. PMID: 15215253
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