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IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo.
Sommereyns C, Paul S, Staeheli P, Michiels T. Sommereyns C, et al. Among authors: staeheli p. PLoS Pathog. 2008 Mar 14;4(3):e1000017. doi: 10.1371/journal.ppat.1000017. PLoS Pathog. 2008. PMID: 18369468 Free PMC article.
Neurons produce type I interferon during viral encephalitis.
Delhaye S, Paul S, Blakqori G, Minet M, Weber F, Staeheli P, Michiels T. Delhaye S, et al. Among authors: staeheli p. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7835-40. doi: 10.1073/pnas.0602460103. Epub 2006 May 8. Proc Natl Acad Sci U S A. 2006. PMID: 16682623 Free PMC article.
An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity.
Ank N, Iversen MB, Bartholdy C, Staeheli P, Hartmann R, Jensen UB, Dagnaes-Hansen F, Thomsen AR, Chen Z, Haugen H, Klucher K, Paludan SR. Ank N, et al. Among authors: staeheli p. J Immunol. 2008 Feb 15;180(4):2474-85. doi: 10.4049/jimmunol.180.4.2474. J Immunol. 2008. PMID: 18250457
Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses.
Mordstein M, Kochs G, Dumoutier L, Renauld JC, Paludan SR, Klucher K, Staeheli P. Mordstein M, et al. Among authors: staeheli p. PLoS Pathog. 2008 Sep 12;4(9):e1000151. doi: 10.1371/journal.ppat.1000151. PLoS Pathog. 2008. PMID: 18787692 Free PMC article.
Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections.
Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, Falcone V, Sorgeloos F, Ehl S, Mayer D, Kochs G, Schwemmle M, Günther S, Drosten C, Michiels T, Staeheli P. Mordstein M, et al. Among authors: staeheli p. J Virol. 2010 Jun;84(11):5670-7. doi: 10.1128/JVI.00272-10. Epub 2010 Mar 24. J Virol. 2010. PMID: 20335250 Free PMC article.
IFN-lambda determines the intestinal epithelial antiviral host defense.
Pott J, Mahlakõiv T, Mordstein M, Duerr CU, Michiels T, Stockinger S, Staeheli P, Hornef MW. Pott J, et al. Among authors: staeheli p. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7944-9. doi: 10.1073/pnas.1100552108. Epub 2011 Apr 25. Proc Natl Acad Sci U S A. 2011. PMID: 21518880 Free PMC article.
Human but not mouse hepatocytes respond to interferon-lambda in vivo.
Hermant P, Demarez C, Mahlakõiv T, Staeheli P, Meuleman P, Michiels T. Hermant P, et al. Among authors: staeheli p. PLoS One. 2014 Jan 31;9(1):e87906. doi: 10.1371/journal.pone.0087906. eCollection 2014. PLoS One. 2014. PMID: 24498220 Free PMC article.
Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections.
Mahlakõiv T, Hernandez P, Gronke K, Diefenbach A, Staeheli P. Mahlakõiv T, et al. Among authors: staeheli p. PLoS Pathog. 2015 Apr 7;11(4):e1004782. doi: 10.1371/journal.ppat.1004782. eCollection 2015 Apr. PLoS Pathog. 2015. PMID: 25849543 Free PMC article.
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.
Hernández PP, Mahlakoiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F, Gronke K, Ryffel B, Hoelscher C, Dumoutier L, Renauld JC, Suerbaum S, Staeheli P, Diefenbach A. Hernández PP, et al. Among authors: staeheli p. Nat Immunol. 2015 Jul;16(7):698-707. doi: 10.1038/ni.3180. Epub 2015 May 25. Nat Immunol. 2015. PMID: 26006013 Free PMC article.
Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.
Pfefferkorn C, Kallfass C, Lienenklaus S, Spanier J, Kalinke U, Rieder M, Conzelmann KK, Michiels T, Staeheli P. Pfefferkorn C, et al. Among authors: staeheli p. J Virol. 2015 Dec 9;90(4):2031-8. doi: 10.1128/JVI.02979-15. Print 2016 Feb 15. J Virol. 2015. PMID: 26656686 Free PMC article.
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