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When the Clock stops ticking, metabolic syndrome explodes.
Staels B. Staels B. Nat Med. 2006 Jan;12(1):54-5; discussion 55. doi: 10.1038/nm0106-54. Nat Med. 2006. PMID: 16397568 No abstract available.
Transient increase in obese gene expression after food intake or insulin administration.
Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. Saladin R, et al. Among authors: staels b. Nature. 1995 Oct 12;377(6549):527-9. doi: 10.1038/377527a0. Nature. 1995. PMID: 7566150
Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function.
Bricambert J, Favre D, Brajkovic S, Bonnefond A, Boutry R, Salvi R, Plaisance V, Chikri M, Chinetti-Gbaguidi G, Staels B, Giusti V, Caiazzo R, Pattou F, Waeber G, Froguel P, Abderrahmani A. Bricambert J, et al. Among authors: staels b. Mol Metab. 2016 Oct 5;5(12):1200-1207. doi: 10.1016/j.molmet.2016.09.011. eCollection 2016 Dec. Mol Metab. 2016. PMID: 27900262 Free PMC article.
PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.
Gross B, Pawlak M, Lefebvre P, Staels B. Gross B, et al. Among authors: staels b. Nat Rev Endocrinol. 2017 Jan;13(1):36-49. doi: 10.1038/nrendo.2016.135. Epub 2016 Sep 16. Nat Rev Endocrinol. 2017. PMID: 27636730 Review.
Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors.
Gervois P, Fruchart JC, Staels B. Gervois P, et al. Among authors: staels b. Nat Clin Pract Endocrinol Metab. 2007 Feb;3(2):145-56. doi: 10.1038/ncpendmet0397. Nat Clin Pract Endocrinol Metab. 2007. PMID: 17237841 Review.
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.
Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R. Liang N, et al. Among authors: staels b. Nat Commun. 2019 Apr 11;10(1):1684. doi: 10.1038/s41467-019-09524-z. Nat Commun. 2019. PMID: 30975991 Free PMC article.
Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes.
Oger F, Dubois-Chevalier J, Gheeraert C, Avner S, Durand E, Froguel P, Salbert G, Staels B, Lefebvre P, Eeckhoute J. Oger F, et al. Among authors: staels b. J Biol Chem. 2014 Jan 10;289(2):708-22. doi: 10.1074/jbc.M113.526996. Epub 2013 Nov 27. J Biol Chem. 2014. PMID: 24288131 Free PMC article.
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Deprez-Poulain R, Hennuyer N, Bosc D, Liang WG, Enée E, Marechal X, Charton J, Totobenazara J, Berte G, Jahklal J, Verdelet T, Dumont J, Dassonneville S, Woitrain E, Gauriot M, Paquet C, Duplan I, Hermant P, Cantrelle FX, Sevin E, Culot M, Landry V, Herledan A, Piveteau C, Lippens G, Leroux F, Tang WJ, van Endert P, Staels B, Deprez B. Deprez-Poulain R, et al. Among authors: staels b. Nat Commun. 2015 Sep 23;6:8250. doi: 10.1038/ncomms9250. Nat Commun. 2015. PMID: 26394692 Free PMC article.
Macrophage subsets in atherosclerosis.
Chinetti-Gbaguidi G, Colin S, Staels B. Chinetti-Gbaguidi G, et al. Among authors: staels b. Nat Rev Cardiol. 2015 Jan;12(1):10-7. doi: 10.1038/nrcardio.2014.173. Epub 2014 Nov 4. Nat Rev Cardiol. 2015. PMID: 25367649 Review.
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens.
Brinster S, Lamberet G, Staels B, Trieu-Cuot P, Gruss A, Poyart C. Brinster S, et al. Among authors: staels b. Nature. 2009 Mar 5;458(7234):83-6. doi: 10.1038/nature07772. Nature. 2009. PMID: 19262672
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