Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis.
Stremmel W, Staffer S, Wannhoff A, Pathil A, Chamulitrat W.
Stremmel W, et al. Among authors: staffer s.
FASEB J. 2014 Jul;28(7):3159-70. doi: 10.1096/fj.14-249763. Epub 2014 Apr 9.
FASEB J. 2014.
PMID: 24719358
Thus, iPLA2beta acts as an upstream checkpoint for mechanisms that regulate fatty acid uptake, and its inhibition by UDCA-LPE qualifies this nontoxic compound as a therapeutic candidate for the treatment of NASH.-Stremmel, W., Staffer, S., Wannhoff, A., Pathil, A., …
Thus, iPLA2beta acts as an upstream checkpoint for mechanisms that regulate fatty acid uptake, and its inhibition by UDCA-LPE qualifies this …