Stammers DK - Search Results

1

Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.

Hopkins AL, Ren J, Tanaka H, Baba M, Okamato M, Stuart DI, Stammers DK. Hopkins AL, et al. Among authors: stammers dk. J Med Chem. 1999 Nov 4;42(22):4500-5. doi: 10.1021/jm990192c. J Med Chem. 1999. PMID: 10579814

2

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.

Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK. Hopkins AL, et al. Among authors: stammers dk. J Med Chem. 2004 Nov 18;47(24):5912-22. doi: 10.1021/jm040071z. J Med Chem. 2004. PMID: 15537346

3

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.

Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH. Freeman GA, et al. Among authors: stammers dk. J Med Chem. 2004 Nov 18;47(24):5923-36. doi: 10.1021/jm040072r. J Med Chem. 2004. PMID: 15537347

4

The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design.

Ren J, Esnouf R, Hopkins A, Ross C, Jones Y, Stammers D, Stuart D. Ren J, et al. Structure. 1995 Sep 15;3(9):915-26. doi: 10.1016/S0969-2126(01)00226-X. Structure. 1995. PMID: 8535785 Free article.

5

Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.

Ren J, Esnouf RM, Hopkins AL, Warren J, Balzarini J, Stuart DI, Stammers DK. Ren J, et al. Among authors: stammers dk. Biochemistry. 1998 Oct 13;37(41):14394-403. doi: 10.1021/bi981309m. Biochemistry. 1998. PMID: 9772165

6

Allosteric inhibitors against HIV-1 reverse transcriptase: design and synthesis of MKC-442 analogues having an omega-functionalized acyclic structure.

Tanaka H, Walker RT, Hopkins AL, Ren J, Jones EY, Fujimoto K, Hayashi M, Miyasaka T, Baba M, Stammers DK, Stuart DI. Tanaka H, et al. Among authors: stammers dk. Antivir Chem Chemother. 1998 Jul;9(4):325-32. Antivir Chem Chemother. 1998. PMID: 9875411

7

Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.

Ren J, Esnouf RM, Hopkins AL, Stuart DI, Stammers DK. Ren J, et al. Among authors: stammers dk. J Med Chem. 1999 Sep 23;42(19):3845-51. doi: 10.1021/jm990275t. J Med Chem. 1999. PMID: 10508433

8

3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.

Ren J, Esnouf RM, Hopkins AL, Jones EY, Kirby I, Keeling J, Ross CK, Larder BA, Stuart DI, Stammers DK. Ren J, et al. Among authors: stammers dk. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. doi: 10.1073/pnas.95.16.9518. Proc Natl Acad Sci U S A. 1998. PMID: 9689112 Free PMC article.

9

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.

Hopkins AL, Ren J, Esnouf RM, Willcox BE, Jones EY, Ross C, Miyasaka T, Walker RT, Tanaka H, Stammers DK, Stuart DI. Hopkins AL, et al. Among authors: stammers dk. J Med Chem. 1996 Apr 12;39(8):1589-600. doi: 10.1021/jm960056x. J Med Chem. 1996. PMID: 8648598

10

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.

Esnouf RM, Ren J, Hopkins AL, Ross CK, Jones EY, Stammers DK, Stuart DI. Esnouf RM, et al. Among authors: stammers dk. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. doi: 10.1073/pnas.94.8.3984. Proc Natl Acad Sci U S A. 1997. PMID: 9108091 Free PMC article.

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