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Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model.
Weber LW, Boll M, Stampfl A. Weber LW, et al. Crit Rev Toxicol. 2003;33(2):105-36. doi: 10.1080/713611034. Crit Rev Toxicol. 2003. PMID: 12708612 Review.
None of these processes per se is considered the ultimate cause of CCl4-induced cell death; it is by cooperation that they achieve a fatal outcome, provided the toxicant acts in a high single dose, or over longer periods of time at low doses. ...Interleukin (IL)-6, …
None of these processes per se is considered the ultimate cause of CCl4-induced cell death; it is by cooperation that they achieve a
Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins.
Weber LW, Boll M, Stampfl A. Weber LW, et al. World J Gastroenterol. 2004 Nov 1;10(21):3081-7. doi: 10.3748/wjg.v10.i21.3081. World J Gastroenterol. 2004. PMID: 15457548 Free PMC article. Review.
The SCAP molecule contains a sterol sensory domain. In the presence of high cellular sterol concentrations SCAP confines SREBP to the ER. ...SREBP-1a and -1c are isoforms produced from a single gene by alternate splicing. SREBP-2 is encoded by a different gen …
The SCAP molecule contains a sterol sensory domain. In the presence of high cellular sterol concentrations SCAP confines SREBP to the …
Cardiovascular responses in unrestrained WKY rats to inhaled ultrafine carbon particles.
Harder V, Gilmour P, Lentner B, Karg E, Takenaka S, Ziesenis A, Stampfl A, Kodavanti U, Heyder J, Schulz H. Harder V, et al. Inhal Toxicol. 2005 Jan;17(1):29-42. doi: 10.1080/08958370590885681. Inhal Toxicol. 2005. PMID: 15764481
We therefore examined cardiovascular effects of UFP in a controlled animal exposure on young, healthy WKY rats. Short-term exposure (24 h) to carbon UFPs (38 nm, 180 microg m (-3)), generated by spark discharging, induced a mild but consistent increase in heart rate …
We therefore examined cardiovascular effects of UFP in a controlled animal exposure on young, healthy WKY rats. Short-term exposure ( …
The enzyme inducers 3-methylcholanthrene and phenobarbital affect the activities of glucocorticoid hormone-regulated enzymes in rat liver and kidney.
Boll M, Weber LW, Font M, Stampfl A. Boll M, et al. Toxicology. 1998 Mar 13;126(2):127-36. doi: 10.1016/s0300-483x(98)00006-7. Toxicology. 1998. PMID: 9620544
The activities of the cytosolic enzymes L-alanine aminotransferase, indoleamine 2,3-dioxygenase (L-tryptophan pyrrolase), phosphoenolpyruvate carboxykinase, L-serine dehydratase and L-tyrosine aminotransferase were affected in a similar fashion: an initial activity reducti …
The activities of the cytosolic enzymes L-alanine aminotransferase, indoleamine 2,3-dioxygenase (L-tryptophan pyrrolase), phosphoenolpyruvat …
In vivo and in vitro studies on the regulatory link between 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in rat liver.
Boll M, Weber LW, Plana J, Stampfl A. Boll M, et al. Z Naturforsch C J Biosci. 1999 May-Jun;54(5-6):371-82. doi: 10.1515/znc-1999-5-612. Z Naturforsch C J Biosci. 1999. PMID: 10431389
Both enzyme activities exhibited the same diurnal rhythm and responded in a coordinate fashion to fasting or bile acid-feeding (decrease) and to cholestyramine-feeding (increase). ...Incubation of hepatocytes with a cholesterol-containing lipoprotein fraction stimul …
Both enzyme activities exhibited the same diurnal rhythm and responded in a coordinate fashion to fasting or bile acid-feeding (decre …
Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites.
Boll M, Weber LW, Becker E, Stampfl A. Boll M, et al. Z Naturforsch C J Biosci. 2001 Jul-Aug;56(7-8):649-59. doi: 10.1515/znc-2001-7-826. Z Naturforsch C J Biosci. 2001. PMID: 11531102
CCl4-induced liver damage was modeled in monolayer cultures of rat primary hepatocytes with a focus on involvement of covalent binding of CCl4 metabolites to cell components and/or peroxidative damage as the cause of injury. (1) Covalent binding of 14C-labeled metabolites …
CCl4-induced liver damage was modeled in monolayer cultures of rat primary hepatocytes with a focus on involvement of covalent bindin …
Pathogenesis of carbon tetrachloride-induced hepatocyte injury bioactivation of CCI4 by cytochrome P450 and effects on lipid homeostasis.
Boll M, Weber LW, Becker E, Stampfl A. Boll M, et al. Z Naturforsch C J Biosci. 2001 Jan-Feb;56(1-2):111-21. doi: 10.1515/znc-2001-1-218. Z Naturforsch C J Biosci. 2001. PMID: 11302200
Ethanol or a high dose of insulin plus triiodothyronine had the same effect. (2) CCl4 increased the synthesis of fatty acids and triglycerides and the rate of lipid esterification. ...Hydrolysis of triglycerides was also reduced. (4) The content of unsaturated fatty acids …
Ethanol or a high dose of insulin plus triiodothyronine had the same effect. (2) CCl4 increased the synthesis of fatty acids and trig …
Hepatocyte damage induced by carbon tetrachloride: inhibited lipoprotein secretion and changed lipoprotein composition.
Boll M, Weber LW, Becker E, Stampfl A. Boll M, et al. Z Naturforsch C J Biosci. 2001 Mar-Apr;56(3-4):283-90. doi: 10.1515/znc-2001-3-419. Z Naturforsch C J Biosci. 2001. PMID: 11371022
VLDL- and HDL-associated cholesterol was not affected, while secretion of phospholipids was increased. (3) Hepatocytes secreted the apolipoproteins B48, B100, E, C, and A-I. ...
VLDL- and HDL-associated cholesterol was not affected, while secretion of phospholipids was increased. (3) Hepatocytes secreted the apolipop …
Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells.
Swiatek-De Lange M, Stampfl A, Hauck SM, Zischka H, Gloeckner CJ, Deeg CA, Ueffing M. Swiatek-De Lange M, et al. Among authors: stampfl a. Glia. 2007 Aug 1;55(10):1061-73. doi: 10.1002/glia.20523. Glia. 2007. PMID: 17551930
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