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The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes.
Tomai MA, Imbertson LM, Stanczak TL, Tygrett LT, Waldschmidt TJ. Tomai MA, et al. Among authors: stanczak tl. Cell Immunol. 2000 Jul 10;203(1):55-65. doi: 10.1006/cimm.2000.1673. Cell Immunol. 2000. PMID: 10915562
Imiquimod 5-percent cream does not alter the natural history of recurrent herpes genitalis: a phase II, randomized, double-blind, placebo-controlled study.
Schacker TW, Conant M, Thoming C, Stanczak T, Wang Z, Smith M. Schacker TW, et al. Among authors: stanczak t. Antimicrob Agents Chemother. 2002 Oct;46(10):3243-8. doi: 10.1128/aac.46.10.3243-3248.2002. Antimicrob Agents Chemother. 2002. PMID: 12234851 Free PMC article. Clinical Trial.