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Year Number of Results
1999 1
2001 1
2003 1
2004 1
2005 1
2006 1
2009 2
2010 1
2012 2
2013 1
2014 1
2015 2
2016 3
2017 3
2018 3
2019 2
2020 3
2021 0
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Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods.
Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V. Casati S, et al. Arch Toxicol. 2018 Feb;92(2):611-617. doi: 10.1007/s00204-017-2097-4. Epub 2017 Nov 10. Arch Toxicol. 2018. PMID: 29127450 Free PMC article.
With the aim to further enhance regulatory consideration and adoption of defined approaches, the European Union Reference Laboratory for Alternatives to Animal testing in collaboration with the International Cooperation on Alternative Test Methods hosted, on …
With the aim to further enhance regulatory consideration and adoption of defined approaches, the European Union Reference
Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.
Reisinger K, Hoffmann S, Alépée N, Ashikaga T, Barroso J, Elcombe C, Gellatly N, Galbiati V, Gibbs S, Groux H, Hibatallah J, Keller D, Kern P, Klaric M, Kolle S, Kuehnl J, Lambrechts N, Lindstedt M, Millet M, Martinozzi-Teissier S, Natsch A, Petersohn D, Pike I, Sakaguchi H, Schepky A, Tailhardat M, Templier M, van Vliet E, Maxwell G. Reisinger K, et al. Toxicol In Vitro. 2015 Feb;29(1):259-70. doi: 10.1016/j.tiv.2014.10.018. Toxicol In Vitro. 2015. PMID: 25448812 Free article.
As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitization potency prediction. .. …
As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined
State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies.
Ezendam J, Braakhuis HM, Vandebriel RJ. Ezendam J, et al. Arch Toxicol. 2016 Dec;90(12):2861-2883. doi: 10.1007/s00204-016-1842-4. Epub 2016 Sep 14. Arch Toxicol. 2016. PMID: 27629427 Review.
Our review shows that some of the defined approaches to testing and assessment are able to accurately predict skin sensitization hazard, sometimes even more accurate than the currently used animal test. A few defined approaches are develo …
Our review shows that some of the defined approaches to testing and assessment are able to accurately predict skin s
A review of substances found positive in 1 of 3 in vitro tests for skin sensitization.
Kolle SN, Natsch A, Gerberick GF, Landsiedel R. Kolle SN, et al. Regul Toxicol Pharmacol. 2019 Aug;106:352-368. doi: 10.1016/j.yrtph.2019.05.016. Epub 2019 May 18. Regul Toxicol Pharmacol. 2019. PMID: 31112722 Free article.
There has been significant progress in recent years in the development and application of alternative methods for assessing the skin sensitization potential of chemicals. The pathways involved in skin sensitization have been described in an OECD advers …
There has been significant progress in recent years in the development and application of alternative methods for assessing the skin
Skin sensitization in silico protocol.
Johnson C, Ahlberg E, Anger LT, Beilke L, Benigni R, Bercu J, Bobst S, Bower D, Brigo A, Campbell S, Cronin MTD, Crooks I, Cross KP, Doktorova T, Exner T, Faulkner D, Fearon IM, Fehr M, Gad SC, Gervais V, Giddings A, Glowienke S, Hardy B, Hasselgren C, Hillegass J, Jolly R, Krupp E, Lomnitski L, Magby J, Mestres J, Milchak L, Miller S, Muster W, Neilson L, Parakhia R, Parenty A, Parris P, Paulino A, Paulino AT, Roberts DW, Schlecker H, Stidl R, Suarez-Rodrigez D, Szabo DT, Tice RR, Urbisch D, Vuorinen A, Wall B, Weiler T, White AT, Whritenour J, Wichard J, Woolley D, Zwickl C, Myatt GJ. Johnson C, et al. Regul Toxicol Pharmacol. 2020 Oct;116:104688. doi: 10.1016/j.yrtph.2020.104688. Epub 2020 Jul 1. Regul Toxicol Pharmacol. 2020. PMID: 32621976 Free article.
In this contribution, the relationship between skin sensitization relevant effects, mechanisms, and endpoints are built into a hazard assessment framework. ...This skin sensitization protocol supports the implementation and acceptance of in silico a
In this contribution, the relationship between skin sensitization relevant effects, mechanisms, and endpoints are built into a …
Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh.
Kolle SN, Landsiedel R. Kolle SN, et al. Handb Exp Pharmacol. 2020 Nov 3. doi: 10.1007/164_2020_368. Online ahead of print. Handb Exp Pharmacol. 2020. PMID: 33136188
Quandaries associated with the validation towards reference data from in vivo animal studies with limited accuracy and limited human relevance are discussed, as well as uncertainty and limitations arising from restricted applicability and technical and biological variance …
Quandaries associated with the validation towards reference data from in vivo animal studies with limited accuracy and limited human …
Applying non-animal strategies for assessing skin sensitisation report from an EPAA/cefic-LRI/IFRA Europe cross sector workshop, ECHA helsinki, February 7th and 8th 2019.
Basketter D, Azam P, Casati S, Corvaro M, Ezendam J, Griem P, Hubesch B, Irizar A, Kern P, Manou I, Mehling A, Rossi LH. Basketter D, et al. Regul Toxicol Pharmacol. 2019 Dec;109:104477. doi: 10.1016/j.yrtph.2019.104477. Epub 2019 Oct 3. Regul Toxicol Pharmacol. 2019. PMID: 31586681 Free article.
Four years on since the last cross sector workshop, experience of the practical application and interpretation of several non-animal assays that contribute to the predictive identification of skin sensitisers has begun to accumulate. Non-animal methods used for haza …
Four years on since the last cross sector workshop, experience of the practical application and interpretation of several non-animal assays …
Accounting for Precision Uncertainty of Toxicity Testing: Methods to Define Borderline Ranges and Implications for Hazard Assessment of Chemicals.
Gabbert S, Mathea M, Kolle SN, Landsiedel R. Gabbert S, et al. Risk Anal. 2020 Dec 9. doi: 10.1111/risa.13648. Online ahead of print. Risk Anal. 2020. PMID: 33300210
Borderline ranges (BR) around the CT were suggested, which represent ranges in which the study result is ambiguous, that is, positive or negative results are equally likely. The BR reflects a method's precision uncertainty. This article explores and compares different a
Borderline ranges (BR) around the CT were suggested, which represent ranges in which the study result is ambiguous, that is, positive or neg …
Review of Diagnostic Challenges in Occupational Asthma.
Pralong JA, Cartier A. Pralong JA, et al. Curr Allergy Asthma Rep. 2017 Jan;17(1):1. doi: 10.1007/s11882-017-0676-3. Curr Allergy Asthma Rep. 2017. PMID: 28091866 Review.
Serial monitoring of peak expiratory flows (PEF), NSBR, and airway inflammation at and off work may confirm the diagnosis of OA but are often difficult to perform. Confirming sensitization by skin prick tests or specific IgE may help to support the diagnosis of OA. …
Serial monitoring of peak expiratory flows (PEF), NSBR, and airway inflammation at and off work may confirm the diagnosis of OA but are ofte …
Consensus report on the future of animal-free systemic toxicity testing.
Leist M, Hasiwa N, Rovida C, Daneshian M, Basketter D, Kimber I, Clewell H, Gocht T, Goldberg A, Busquet F, Rossi AM, Schwarz M, Stephens M, Taalman R, Knudsen TB, McKim J, Harris G, Pamies D, Hartung T. Leist M, et al. ALTEX. 2014;31(3):341-56. doi: 10.14573/altex.1406091. ALTEX. 2014. PMID: 25061899 Free article.
However, in other fields as well, traditional animal experimentation does not always satisfy requirements in safety testing, as the need for human-relevant information is ever increasing. A general strategy for animal-free test approaches was outlined by the US National Re …
However, in other fields as well, traditional animal experimentation does not always satisfy requirements in safety testing, as the need for …
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