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Page 1
A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells.
Calvo V, Zheng W, Adam-Artigues A, Staschke KA, Huang X, Cheung JF, Nobre AR, Fujisawa S, Liu D, Fumagalli M, Surguladze D, Stokes ME, Nowacek A, Mulvihill M, Farias EF, Aguirre-Ghiso JA. Calvo V, et al. Among authors: staschke ka. Clin Cancer Res. 2023 Dec 15;29(24):5155-5172. doi: 10.1158/1078-0432.CCR-23-1427. Clin Cancer Res. 2023. PMID: 37982738 Free PMC article.
Activation of Gcn2 by small molecules designed to be inhibitors.
Carlson KR, Georgiadis MM, Tameire F, Staschke KA, Wek RC. Carlson KR, et al. Among authors: staschke ka. J Biol Chem. 2023 Apr;299(4):104595. doi: 10.1016/j.jbc.2023.104595. Epub 2023 Mar 8. J Biol Chem. 2023. PMID: 36898579 Free PMC article.
Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice.
Muralidharan C, Huang F, Enriquez JR, Wang JE, Nelson JB, Nargis T, May SC, Chakraborty A, Figatner KT, Navitskaya S, Anderson CM, Calvo V, Surguladze D, Mulvihill MJ, Yi X, Sarkar S, Oakes SA, Webb-Robertson BM, Sims EK, Staschke KA, Eizirik DL, Nakayasu ES, Stokes ME, Tersey SA, Mirmira RG. Muralidharan C, et al. Among authors: staschke ka. J Clin Invest. 2024 Jun 18;134(16):e176136. doi: 10.1172/JCI176136. J Clin Invest. 2024. PMID: 38889047 Free PMC article.
Asparagine bioavailability regulates the translation of MYC oncogene.
Srivastava S, Jiang J, Misra J, Seim G, Staschke KA, Zhong M, Zhou L, Liu Y, Chen C, Davé U, Kapur R, Batra S, Zhang C, Zhou J, Fan J, Wek RC, Zhang J. Srivastava S, et al. Among authors: staschke ka. Oncogene. 2022 Oct;41(44):4855-4865. doi: 10.1038/s41388-022-02474-9. Epub 2022 Oct 1. Oncogene. 2022. PMID: 36182969 Free PMC article.
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.
Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, Wek RC, Staschke KA. Cordova RA, et al. Among authors: staschke ka. Elife. 2022 Sep 15;11:e81083. doi: 10.7554/eLife.81083. Elife. 2022. PMID: 36107759 Free PMC article.
Adapting to cell stress from inside and out.
Staschke KA, Wek RC. Staschke KA, et al. Nat Cell Biol. 2019 Jul;21(7):799-800. doi: 10.1038/s41556-019-0354-x. Nat Cell Biol. 2019. PMID: 31263267 No abstract available.
Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice.
Muralidharan C, Huang F, Enriquez JR, Wang JE, Nelson JB, Nargis T, May SC, Chakraborty A, Figatner KT, Navitskaya S, Anderson CM, Calvo V, Surguladze D, Mulvihill MJ, Yi X, Sarkar S, Oakes SA, Webb-Robertson BM, Sims EK, Staschke KA, Eizirik DL, Nakayasu ES, Stokes ME, Tersey SA, Mirmira RG. Muralidharan C, et al. Among authors: staschke ka. bioRxiv [Preprint]. 2024 Jun 3:2023.10.06.561126. doi: 10.1101/2023.10.06.561126. bioRxiv. 2024. Update in: J Clin Invest. 2024 Jun 18;134(16):e176136. doi: 10.1172/JCI176136. PMID: 38895427 Free PMC article. Updated. Preprint.
27 results