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Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering.
Stassi DL, Kakavas SJ, Reynolds KA, Gunawardana G, Swanson S, Zeidner D, Jackson M, Liu H, Buko A, Katz L. Stassi DL, et al. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7305-9. doi: 10.1073/pnas.95.13.7305. Proc Natl Acad Sci U S A. 1998. PMID: 9636144 Free PMC article.
Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.
Ruan X, Pereda A, Stassi DL, Zeidner D, Summers RG, Jackson M, Shivakumar A, Kakavas S, Staver MJ, Donadio S, Katz L. Ruan X, et al. Among authors: stassi dl. J Bacteriol. 1997 Oct;179(20):6416-25. doi: 10.1128/jb.179.20.6416-6425.1997. J Bacteriol. 1997. PMID: 9335291 Free PMC article.
The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea.
Pereda A, Summers RG, Stassi DL, Ruan X, Katz L. Pereda A, et al. Among authors: stassi dl. Microbiology. 1998 Feb;144 ( Pt 2):543-53. doi: 10.1099/00221287-144-2-543. Microbiology. 1998. PMID: 9493390
Gene disruption and replacement in the rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253.
Lomovskaya N, Fonstein L, Ruan X, Stassi D, Katz L, Hutchinson CR. Lomovskaya N, et al. Among authors: stassi d. Microbiology. 1997 Mar;143 ( Pt 3):875-83. doi: 10.1099/00221287-143-3-875. Microbiology. 1997. PMID: 9084171
A genetically engineered strain of Saccharopolyspora erythraea that produces 6,12-dideoxyerythromycin A as the major fermentation product.
Stassi D, Post D, Satter M, Jackson M, Maine G. Stassi D, et al. Appl Microbiol Biotechnol. 1998 Jun;49(6):725-31. doi: 10.1007/s002530051238. Appl Microbiol Biotechnol. 1998. PMID: 9684306
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