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Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms.
Okuyama H, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, Uchino H. Okuyama H, et al. Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99. doi: 10.1586/17512433.2015.1011125. Epub 2015 Feb 6. Expert Rev Clin Pharmacol. 2015. PMID: 25655639
An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency. Thus, the epidemic of heart failure and atherosclerosis that plagues the modern w …
An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyop …
Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes.
Okuyama H, Langsjoen PH, Ohara N, Hashimoto Y, Hamazaki T, Yoshida S, Kobayashi T, Langsjoen AM. Okuyama H, et al. Pharmacology. 2016;98(3-4):134-70. doi: 10.1159/000446704. Epub 2016 Jun 2. Pharmacology. 2016. PMID: 27251151 Review.
SUMMARY: Statin-induced suppression of prenyl intermediates in the cholesterol biosynthetic pathway has been linked to stimulated atherosclerosis and heart failure. ...These vegetable oils and medicines such as statin and warfarin share, …
SUMMARY: Statin-induced suppression of prenyl intermediates in the cholesterol biosynthetic pathway has been linked to stimulated …
Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering.
Gounari P, Tousoulis D, Antoniades C, Kampoli AM, Stougiannos P, Papageorgiou N, Roulia G, Stefanadi E, Siasos G, Tsioufis C, Stefanadis C. Gounari P, et al. Int J Cardiol. 2010 Jun 25;142(1):87-91. doi: 10.1016/j.ijcard.2008.12.067. Epub 2009 Feb 6. Int J Cardiol. 2010. PMID: 19200613 Clinical Trial.
INTRODUCTION: Congestive heart failure (HF) is characterised by increased proinflammatory stimulation and impaired endothelial function. ...These findings indicate a direct beneficial effect of statins in patients with congestive heart failur …
INTRODUCTION: Congestive heart failure (HF) is characterised by increased proinflammatory stimulation and impaired endo …