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Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms.
Okuyama H, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T, Uchino H. Okuyama H, et al. Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99. doi: 10.1586/17512433.2015.1011125. Epub 2015 Feb 6. Expert Rev Clin Pharmacol. 2015. PMID: 25655639
In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function i …
In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective …
Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes.
Okuyama H, Langsjoen PH, Ohara N, Hashimoto Y, Hamazaki T, Yoshida S, Kobayashi T, Langsjoen AM. Okuyama H, et al. Pharmacology. 2016;98(3-4):134-70. doi: 10.1159/000446704. Epub 2016 Jun 2. Pharmacology. 2016. PMID: 27251151 Free article. Review.
Nevertheless, guidelines from relevant medical societies recommend using cholesterol lowering medication (statin) for both types of patients. Medicines with several different action mechanisms have been developed, and the effectiveness of different lifestyle modific …
Nevertheless, guidelines from relevant medical societies recommend using cholesterol lowering medication (statin) for both types of p …
Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering.
Gounari P, Tousoulis D, Antoniades C, Kampoli AM, Stougiannos P, Papageorgiou N, Roulia G, Stefanadi E, Siasos G, Tsioufis C, Stefanadis C. Gounari P, et al. Int J Cardiol. 2010 Jun 25;142(1):87-91. doi: 10.1016/j.ijcard.2008.12.067. Epub 2009 Feb 6. Int J Cardiol. 2010. PMID: 19200613 Clinical Trial.
INTRODUCTION: Congestive heart failure (HF) is characterised by increased proinflammatory stimulation and impaired endothelial function. ...These findings indicate a direct beneficial effect of statins in patients with congestive heart failur …
INTRODUCTION: Congestive heart failure (HF) is characterised by increased proinflammatory stimulation and impaired endo …