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Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3.
Boulkroun S, Ruffieux-Daidié D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D, Firsov D, Kellenberger S, Staub O. Boulkroun S, et al. Among authors: Staub O. Am J Physiol Renal Physiol. 2008 Oct;295(4):F889-900. doi: 10.1152/ajprenal.00001.2008. Epub 2008 Jul 16. Am J Physiol Renal Physiol. 2008. PMID: 18632802
Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.
Wang MX, Su XT, Wu P, Gao ZX, Wang WH, Staub O, Lin DH. Wang MX, et al. Among authors: Staub O. Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F986-F996. doi: 10.1152/ajprenal.00059.2018. Epub 2018 Jun 13. Am J Physiol Renal Physiol. 2018. PMID: 29897283 Free PMC article.
WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter.
Lagnaz D, Arroyo JP, Chávez-Canales M, Vázquez N, Rizzo F, Spirlí A, Debonneville A, Staub O, Gamba G. Lagnaz D, et al. Among authors: Staub O. Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F275-86. doi: 10.1152/ajprenal.00574.2013. Epub 2014 Jun 11. Am J Physiol Renal Physiol. 2014. PMID: 24920754
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.
Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O. Ronzaud C, et al. Among authors: Staub O. J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348737 Free PMC article.
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