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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T, Lehmann JM. Kliewer SA, et al. Among authors: Staudinger JL. Cell. 1998 Jan 9;92(1):73-82. doi: 10.1016/s0092-8674(00)80900-9. Cell. 1998. PMID: 9489701
CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11.
Anakk S, Kalsotra A, Kikuta Y, Huang W, Zhang J, Staudinger JL, Moore DD, Strobel HW. Anakk S, et al. Among authors: Staudinger JL. Pharmacogenomics J. 2004;4(2):91-101. doi: 10.1038/sj.tpj.6500222. Pharmacogenomics J. 2004. PMID: 14770174
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. Staudinger JL, et al. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74. doi: 10.1073/pnas.051551698. Proc Natl Acad Sci U S A. 2001. PMID: 11248085 Free PMC article.
Gender dictates the nuclear receptor-mediated regulation of CYP3A44.
Anakk S, Huang W, Staudinger JL, Tan K, Cole TJ, Moore DD, Strobel HW. Anakk S, et al. Among authors: Staudinger JL. Drug Metab Dispos. 2007 Jan;35(1):36-42. doi: 10.1124/dmd.106.011270. Epub 2006 Oct 4. Drug Metab Dispos. 2007. PMID: 17020958
Protein kinase C as a transducer of nuclear signals.
Olson EN, Burgess R, Staudinger J. Olson EN, et al. Among authors: Staudinger J. Cell Growth Differ. 1993 Aug;4(8):699-705. Cell Growth Differ. 1993. PMID: 8398911 Review. No abstract available.
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