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Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.
Robey RW, Shukla S, Steadman K, Obrzut T, Finley EM, Ambudkar SV, Bates SE. Robey RW, et al. Mol Cancer Ther. 2007 Jun;6(6):1877-85. doi: 10.1158/1535-7163.MCT-06-0811. Mol Cancer Ther. 2007. PMID: 17575116
The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems.
Goldsmith ME, Aguila A, Steadman K, Martinez A, Steinberg SM, Alley MC, Waud WR, Bates SE, Fojo T. Goldsmith ME, et al. Mol Cancer Ther. 2007 Feb;6(2):496-505. doi: 10.1158/1535-7163.MCT-06-0431. Mol Cancer Ther. 2007. PMID: 17308048
Single nucleotide polymorphisms modify the transporter activity of ABCG2.
Morisaki K, Robey RW, Ozvegy-Laczka C, Honjo Y, Polgar O, Steadman K, Sarkadi B, Bates SE. Morisaki K, et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):161-72. doi: 10.1007/s00280-004-0931-x. Epub 2005 Apr 19. Cancer Chemother Pharmacol. 2005. PMID: 15838659
Pheophorbide a is a specific probe for ABCG2 function and inhibition.
Robey RW, Steadman K, Polgar O, Morisaki K, Blayney M, Mistry P, Bates SE. Robey RW, et al. Cancer Res. 2004 Feb 15;64(4):1242-6. doi: 10.1158/0008-5472.can-03-3298. Cancer Res. 2004. PMID: 14973080
Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma.
Bates SE, Zhan Z, Steadman K, Obrzut T, Luchenko V, Frye R, Robey RW, Turner M, Gardner ER, Figg WD, Steinberg SM, Ling A, Fojo T, To KW, Piekarz RL. Bates SE, et al. Br J Haematol. 2010 Jan;148(2):256-67. doi: 10.1111/j.1365-2141.2009.07954.x. Epub 2009 Oct 28. Br J Haematol. 2010. PMID: 19874311 Free PMC article. Clinical Trial.
Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen.
Deeken JF, Robey RW, Shukla S, Steadman K, Chakraborty AR, Poonkuzhali B, Schuetz EG, Holbeck S, Ambudkar SV, Bates SE. Deeken JF, et al. Mol Pharmacol. 2009 Nov;76(5):946-56. doi: 10.1124/mol.109.056192. Epub 2009 Jul 24. Mol Pharmacol. 2009. PMID: 19633067 Free PMC article.
Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr(-/-) murine model of autoimmune lymphoproliferative syndrome (ALPS).
Dowdell KC, Pesnicak L, Hoffmann V, Steadman K, Remaley AT, Cohen JI, Straus SE, Rao VK. Dowdell KC, et al. Exp Hematol. 2009 Apr;37(4):487-94. doi: 10.1016/j.exphem.2008.12.002. Epub 2009 Feb 12. Exp Hematol. 2009. PMID: 19217201 Free PMC article.
Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
Panicker J, Li Z, McMahon C, Sizer C, Steadman K, Piekarz R, Bates SE, Thiele CJ. Panicker J, et al. Cell Cycle. 2010 May;9(9):1830-8. doi: 10.4161/cc.9.9.11543. Epub 2010 May 15. Cell Cycle. 2010. PMID: 20404560 Free PMC article.
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