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After TGN1412: recent developments in cytokine release assays.
Stebbings R, Eastwood D, Poole S, Thorpe R. Stebbings R, et al. J Immunotoxicol. 2013 Jan-Mar;10(1):75-82. doi: 10.3109/1547691X.2012.711783. Epub 2012 Sep 11. J Immunotoxicol. 2013. PMID: 22967038 Free PMC article.
"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.
Stebbings R, Findlay L, Edwards C, Eastwood D, Bird C, North D, Mistry Y, Dilger P, Liefooghe E, Cludts I, Fox B, Tarrant G, Robinson J, Meager T, Dolman C, Thorpe SJ, Bristow A, Wadhwa M, Thorpe R, Poole S. Stebbings R, et al. J Immunol. 2007 Sep 1;179(5):3325-31. doi: 10.4049/jimmunol.179.5.3325. J Immunol. 2007. PMID: 17709549
Resistance to superinfection by a vigorously replicating, uncloned stock of simian immunodeficiency virus (SIVmac251) stimulates replication of a live attenuated virus vaccine (SIVmacC8).
Berry N, Stebbings R, Ferguson D, Ham C, Alden J, Brown S, Jenkins A, Lines J, Duffy L, Davis L, Elsley W, Page M, Hull R, Stott J, Almond N. Berry N, et al. Among authors: stebbings r. J Gen Virol. 2008 Sep;89(Pt 9):2240-2251. doi: 10.1099/vir.0.2008/001693-0. J Gen Virol. 2008. PMID: 18753233
How do we assure the quality of biological medicines?
Longstaff C, Whitton CM, Stebbings R, Gray E. Longstaff C, et al. Among authors: stebbings r. Drug Discov Today. 2009 Jan;14(1-2):50-5. doi: 10.1016/j.drudis.2008.09.010. Epub 2008 Nov 17. Drug Discov Today. 2009. PMID: 18951998 Review.
Safety of biologics, lessons learnt from TGN1412.
Stebbings R, Poole S, Thorpe R. Stebbings R, et al. Curr Opin Biotechnol. 2009 Dec;20(6):673-7. doi: 10.1016/j.copbio.2009.10.002. Epub 2009 Nov 4. Curr Opin Biotechnol. 2009. PMID: 19892543 Review.
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