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Vaccine-enhanced competition permits rational bacterial strain replacement in the gut.
Lentsch V, Woller A, Rocker A, Aslani S, Moresi C, Ruoho N, Larsson L, Fattinger SA, Wenner N, Barazzone EC, Hardt WD, Loverdo C, Diard M, Slack E. Lentsch V, et al. Among authors: fattinger sa. Science. 2025 Apr 4;388(6742):74-81. doi: 10.1126/science.adp5011. Epub 2025 Apr 3. Science. 2025. PMID: 40179176 Free PMC article.
SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity.
Witt KC, Dziulko A, An J, Pekovic F, Cheng AX, Liu GY, Lee OV, Turner DJ, Lari A, Gaidt MM, Chavez R, Fattinger SA, Abraham P, Dhaliwal H, Lee AY, Kotov DI, Coscoy L, Glaunsinger BA, Valkov E, Chuong EB, Vance RE. Witt KC, et al. Among authors: fattinger sa. Nature. 2025 Jul;643(8074):1372-1380. doi: 10.1038/s41586-025-09152-2. Epub 2025 Jun 11. Nature. 2025. PMID: 40500448 Free PMC article.
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.
Fattinger SA, Maurer L, Geiser P, Bernard EM, Enz U, Ganguillet S, Gül E, Kroon S, Demarco B, Mack V, Furter M, Barthel M, Pelczar P, Shao F, Broz P, Sellin ME, Hardt WD. Fattinger SA, et al. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120. doi: 10.1073/pnas.2315503120. Epub 2023 Nov 21. Proc Natl Acad Sci U S A. 2023. PMID: 37988464 Free PMC article.
The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity.
Witt KC, Dziulko A, An J, Pekovic F, Cheng AX, Liu GY, Lee OV, Turner DJ, Lari A, Gaidt MM, Chavez R, Fattinger SA, Abraham P, Dhaliwal H, Lee AY, Kotov DI, Coscoy L, Glaunsinger BA, Valkov E, Chuong EB, Vance RE. Witt KC, et al. Among authors: fattinger sa. bioRxiv [Preprint]. 2025 Jan 29:2024.08.28.610186. doi: 10.1101/2024.08.28.610186. bioRxiv. 2025. Update in: Nature. 2025 Jul;643(8074):1372-1380. doi: 10.1038/s41586-025-09152-2. PMID: 39974928 Free PMC article. Updated. Preprint.
21 results