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Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans.
Stefan N, Wahl HG, Fritsche A, Häring H, Stumvoll M. Stefan N, et al. Horm Metab Res. 2001 Jul;33(7):432-8. doi: 10.1055/s-2001-16231. Horm Metab Res. 2001. PMID: 11507682 Clinical Trial.
A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.
Fritsche A, Stefan N, Hardt E, Schützenauer S, Häring H, Stumvoll M. Fritsche A, et al. Among authors: stefan n. Eur J Clin Invest. 2000 May;30(5):411-8. doi: 10.1046/j.1365-2362.2000.00649.x. Eur J Clin Invest. 2000. PMID: 10809901 Clinical Trial.
The insulin concentration after the arginine bolus at > 25 mM glucose (n = 6) was 2773 +/- 855 pM vs. 7562 +/- 1168 pM for Imax (P = 0.003). ...
The insulin concentration after the arginine bolus at > 25 mM glucose (n = 6) was 2773 +/- 855 pM vs. 7562 +/- 1168 pM for Imax (P …
A 60 minute hyperglycemic clamp is sufficient to assess both phases of insulin secretion.
Stumvoll M, Fritsche A, Stefan N, Häring H. Stumvoll M, et al. Among authors: stefan n. Horm Metab Res. 2000 Jun;32(6):230-2. doi: 10.1055/s-2007-978626. Horm Metab Res. 2000. PMID: 10898552
Characterisation of beta-cell dysfunction of impaired glucose tolerance: evidence for impairment of incretin-induced insulin secretion.
Fritsche A, Stefan N, Hardt E, Häring H, Stumvoll M. Fritsche A, et al. Among authors: stefan n. Diabetologia. 2000 Jul;43(7):852-8. doi: 10.1007/s001250051461. Diabetologia. 2000. PMID: 10952457
Stimulatory effect of increased non-esterified fatty acid concentrations on proinsulin processing in healthy humans.
Stefan N, Fritsche A, Madaus A, Häring H, Stumvoll M. Stefan N, et al. Diabetologia. 2000 Nov;43(11):1368-73. doi: 10.1007/s001250051540. Diabetologia. 2000. PMID: 11126404
Evidence against a rate-limiting role of proinsulin processing for maximal insulin secretion in subjects with impaired glucose tolerance and beta-cell dysfunction.
Stumvoll M, Fritsche A, Stefan N, Hardt E, Häring H. Stumvoll M, et al. Among authors: stefan n. J Clin Endocrinol Metab. 2001 Mar;86(3):1235-9. doi: 10.1210/jcem.86.3.7331. J Clin Endocrinol Metab. 2001. PMID: 11238514
Acute stimulation of leptin concentrations in humans during hyperglycemic hyperinsulinemia. Influence of free fatty acids and fasting.
Stefan N, Fritsche A, Häring H, Stumvoll M. Stefan N, et al. Int J Obes Relat Metab Disord. 2001 Jan;25(1):138-42. doi: 10.1038/sj.ijo.0801527. Int J Obes Relat Metab Disord. 2001. PMID: 11244470
SUBJECTS: Lean, young, healthy volunteers; control group (n=6), experimental group (n=6). MEASUREMENTS: Serum leptin concentrations. ...
SUBJECTS: Lean, young, healthy volunteers; control group (n=6), experimental group (n=6). MEASUREMENTS: Serum leptin concentra …
The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans.
Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, Teigeler A, Koch M, Machicao F, Häring H. Stumvoll M, et al. Among authors: stefan n. Diabetes. 2001 Apr;50(4):882-5. doi: 10.2337/diabetes.50.4.882. Diabetes. 2001. PMID: 11289056
Several validated indexes of beta-cell function from the oral glucose tolerance test were significantly lower in X/Arg (n = 31) compared with Gly/Gly (n = 181) (P between 0.002 and 0.05), whereas insulin sensitivity (measured with a euglycemic clamp) was not differe …
Several validated indexes of beta-cell function from the oral glucose tolerance test were significantly lower in X/Arg (n = 31) compa …
Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes.
Fritsche A, Stefan N, Häring H, Gerich J, Stumvoll M. Fritsche A, et al. Among authors: stefan n. Ann Intern Med. 2001 May 1;134(9 Pt 1):729-36. doi: 10.7326/0003-4819-134-9_part_1-200105010-00009. Ann Intern Med. 2001. PMID: 11329230 Clinical Trial.
Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene.
Stefan N, Fritsche A, Häring H, Stumvoll M. Stefan N, et al. Diabetes. 2001 May;50(5):1143-8. doi: 10.2337/diabetes.50.5.1143. Diabetes. 2001. PMID: 11334419
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