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IKKβ slows Huntington's disease progression in R6/1 mice.
Ochaba J, Fote G, Kachemov M, Thein S, Yeung SY, Lau AL, Hernandez S, Lim RG, Casale M, Neel MJ, Monuki ES, Reidling J, Housman DE, Thompson LM, Steffan JS. Ochaba J, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10952-10961. doi: 10.1073/pnas.1814246116. Epub 2019 May 14. Proc Natl Acad Sci U S A. 2019. PMID: 31088970 Free PMC article.
Potential function for the Huntingtin protein as a scaffold for selective autophagy.
Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS. Ochaba J, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16889-94. doi: 10.1073/pnas.1420103111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385587 Free PMC article.
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Morozko EL, Smith-Geater C, Monteys AM, Pradhan S, Lim RG, Langfelder P, Kachemov M, Kulkarni JA, Zaifman J, Hill A, Stocksdale JT, Cullis PR, Wu J, Ochaba J, Miramontes R, Chakraborty A, Hazra TK, Lau A, St-Cyr S, Orellana I, Kopan L, Wang KQ, Yeung S, Leavitt BR, Reidling JC, Yang XW, Steffan JS, Davidson BL, Sarkar PS, Thompson LM. Morozko EL, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2021836118. doi: 10.1073/pnas.2021836118. Proc Natl Acad Sci U S A. 2021. PMID: 33468657 Free PMC article.
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.
Hockly E, Richon VM, Woodman B, Smith DL, Zhou X, Rosa E, Sathasivam K, Ghazi-Noori S, Mahal A, Lowden PA, Steffan JS, Marsh JL, Thompson LM, Lewis CM, Marks PA, Bates GP. Hockly E, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6. doi: 10.1073/pnas.0437870100. Epub 2003 Feb 7. Proc Natl Acad Sci U S A. 2003. PMID: 12576549 Free PMC article.
Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.
Aiken CT, Steffan JS, Guerrero CM, Khashwji H, Lukacsovich T, Simmons D, Purcell JM, Menhaji K, Zhu YZ, Green K, Laferla F, Huang L, Thompson LM, Marsh JL. Aiken CT, et al. Among authors: steffan js. J Biol Chem. 2009 Oct 23;284(43):29427-36. doi: 10.1074/jbc.M109.013193. Epub 2009 Aug 26. J Biol Chem. 2009. PMID: 19710014 Free PMC article.
Histone deacetylase inhibitors reduce polyglutamine toxicity.
McCampbell A, Taye AA, Whitty L, Penney E, Steffan JS, Fischbeck KH. McCampbell A, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15179-84. doi: 10.1073/pnas.261400698. Epub 2001 Dec 11. Proc Natl Acad Sci U S A. 2001. PMID: 11742087 Free PMC article.
57 results