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ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes.
Schroeder L, Herwartz C, Jordanovski D, Steger G. Schroeder L, et al. Among authors: steger g. Mediators Inflamm. 2017;2017:1248201. doi: 10.1155/2017/1248201. Epub 2017 Feb 21. Mediators Inflamm. 2017. PMID: 28316371 Free PMC article.
ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is required for ZNF395-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 low. ...
ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is …
The hypoxia-inducible transcription factor ZNF395 is controlled by IĸB kinase-signaling and activates genes involved in the innate immune response and cancer.
Jordanovski D, Herwartz C, Pawlowski A, Taute S, Frommolt P, Steger G. Jordanovski D, et al. Among authors: steger g. PLoS One. 2013 Sep 23;8(9):e74911. doi: 10.1371/journal.pone.0074911. eCollection 2013. PLoS One. 2013. PMID: 24086395 Free PMC article.
To understand the biological activity of ZNF395, we identified target genes of ZNF395 through a genome-wide expression screen. ...In cells that lack ZNF395, the IFN-alpha-mediated stimulation of these factors was impaired, demonstrating that ZNF395 is …
To understand the biological activity of ZNF395, we identified target genes of ZNF395 through a genome-wide expression screen. …
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P. Yao X, et al. Among authors: steger g. Cancer Discov. 2017 Nov;7(11):1284-1305. doi: 10.1158/2159-8290.CD-17-0375. Epub 2017 Sep 11. Cancer Discov. 2017. PMID: 28893800
Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enhancer malfunction in ccRCC, with cognate enhancer-target genes associated with tissue-specific aspects of malignancy. Superenhancer profiling identified ZNF395 a …
Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enhancer malfunction in ccRCC, …
The Transcription Factor ZNF395 Is Required for the Maximal Hypoxic Induction of Proinflammatory Cytokines in U87-MG Cells.
Herwartz C, Castillo-Juárez P, Schröder L, Barron BL, Steger G. Herwartz C, et al. Among authors: steger g. Mediators Inflamm. 2015;2015:804264. doi: 10.1155/2015/804264. Epub 2015 Jul 1. Mediators Inflamm. 2015. PMID: 26229239 Free PMC article.
We show that ZNF395 is a target gene of the hypoxia inducible factor HIF-1alpha. ...At ambient oxygen concentrations, ZNF395 had no enhancing effect, indicating that this transcriptional activation by ZNF395 is restricted to hypoxic conditions. ...
We show that ZNF395 is a target gene of the hypoxia inducible factor HIF-1alpha. ...At ambient oxygen concentrations, ZNF395 h …
HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.
Kirschberg M, Heuser S, Syed AS, Steger G, Majewski S, Hufbauer M, Akgül B. Kirschberg M, et al. Among authors: steger g. Virology. 2019 Sep;535:136-143. doi: 10.1016/j.virol.2019.06.019. Epub 2019 Jul 1. Virology. 2019. PMID: 31299490 Free article.
The human papillomavirus type 8 (HPV8) is associated with skin cancer development. ...
The human papillomavirus type 8 (HPV8) is associated with skin cancer development. ...
Competitive binding of viral E2 protein and mammalian core-binding factor to transcriptional control sequences of human papillomavirus type 8 and bovine papillomavirus type 1.
Schmidt HM, Steger G, Pfister H. Schmidt HM, et al. Among authors: steger g. J Virol. 1997 Oct;71(10):8029-34. doi: 10.1128/JVI.71.10.8029-8034.1997. J Virol. 1997. PMID: 9311900 Free PMC article.
The promoter P7535 of human papillomavirus type 8 and the promoter P7185 of bovine papillomavirus type 1 are negatively regulated by viral E2 proteins via the promoter proximal binding sites P2 and BS1, respectively. ...Competition of CBF and E2 protein for DNA bind …
The promoter P7535 of human papillomavirus type 8 and the promoter P7185 of bovine papillomavirus type 1 are negatively regula …
Human papillomavirus type 8 E6 oncoprotein inhibits transcription of the PDZ protein syntenin-2.
Lazić D, Hufbauer M, Zigrino P, Buchholz S, Kazem S, Feltkamp MC, Mauch C, Steger G, Pfister H, Akgül B. Lazić D, et al. Among authors: steger g. J Virol. 2012 Aug;86(15):7943-52. doi: 10.1128/JVI.00132-12. Epub 2012 May 23. J Virol. 2012. PMID: 22623796 Free PMC article. Clinical Trial.
The E6 proteins from high-risk alpha human papillomavirus (HPV) types (e.g., HPV16) are characterized by the presence of a PDZ-binding motif through which they interact with a number of cellular PDZ domain-containing substrates and cooperate in their degradation. ...
The E6 proteins from high-risk alpha human papillomavirus (HPV) types (e.g., HPV16) are characterized by the presence of a PDZ-bindin …
Prevalence of antibodies to human papillomavirus type 8 in human sera.
Steger G, Olszewsky M, Stockfleth E, Pfister H. Steger G, et al. J Virol. 1990 Sep;64(9):4399-406. doi: 10.1128/JVI.64.9.4399-4406.1990. J Virol. 1990. PMID: 2166821 Free PMC article.
The epidermodysplasia verruciformis-associated human papillomavirus type 8 (HPV-8) poses a high risk for malignant conversion of skin lesions in patients with epidermodysplasia verruciformis. ...
The epidermodysplasia verruciformis-associated human papillomavirus type 8 (HPV-8) poses a high risk for malignant conversion of skin …
Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.
Sichtig N, Körfer N, Steger G. Sichtig N, et al. Among authors: steger g. Arch Biochem Biophys. 2007 Nov 1;467(1):67-75. doi: 10.1016/j.abb.2007.08.015. Epub 2007 Aug 29. Arch Biochem Biophys. 2007. PMID: 17897615
Papillomavirus binding factor, PBF, identical to the Huntington's disease binding protein 2, HDBP2, is a nuclear-cytoplasmic shuttling factor with the ability to inhibit cell growth. It has been identified by its ability to bind to GC-rich sequence elements within upstream …
Papillomavirus binding factor, PBF, identical to the Huntington's disease binding protein 2, HDBP2, is a nuclear-cytoplasmic shuttlin …
Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta.
Sichtig N, Silling S, Steger G. Sichtig N, et al. Among authors: steger g. Arch Biochem Biophys. 2007 Aug 1;464(1):90-9. doi: 10.1016/j.abb.2007.04.017. Epub 2007 May 7. Arch Biochem Biophys. 2007. PMID: 17531190
The cellular factor, papillomavirus (PV)-binding factor (PBF)/Huntington's disease binding protein 2 (HDBP2), was identified by its ability to bind regulatory sequences of certain papillomavirus types as well as the Huntington's disease gene. ...
The cellular factor, papillomavirus (PV)-binding factor (PBF)/Huntington's disease binding protein 2 (HDBP2), was identified by its a …
31 results