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ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma.
Koh J, Liao C, Ng MSW, Hong JH, Heng HL, Gui DY, Wang Z, Chua BY, Li Z, Sobota RM, Lee LS, Iqbal J, Lim KJ, Bezwada D, DeBerardinis RJ, Steger G, Ching J, Tan P, Teh BT, Zhang Q, Yao X. Koh J, et al. Among authors: steger g. Cancer Res. 2026 Apr 2;86(7):1676-1689. doi: 10.1158/0008-5472.CAN-24-4745. Cancer Res. 2026. PMID: 41637546 Free PMC article.
When activated by a HIF2alpha-modulated superenhancer, ZNF395 facilitated the transcription of enzymes essential for glutaminolysis, including glutaminase (GLS) and isocitrate dehydrogenase 2. ...Restoration of mitochondrial complex I function and GLS expression partially …
When activated by a HIF2alpha-modulated superenhancer, ZNF395 facilitated the transcription of enzymes essential for glutaminolysis, …
ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes.
Schroeder L, Herwartz C, Jordanovski D, Steger G. Schroeder L, et al. Among authors: steger g. Mediators Inflamm. 2017;2017:1248201. doi: 10.1155/2017/1248201. Epub 2017 Feb 21. Mediators Inflamm. 2017. PMID: 28316371 Free PMC article.
ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is required for ZNF395-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 low. ...
ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is …
The hypoxia-inducible transcription factor ZNF395 is controlled by IqB kinase-signaling and activates genes involved in the innate immune response and cancer.
Jordanovski D, Herwartz C, Pawlowski A, Taute S, Frommolt P, Steger G. Jordanovski D, et al. Among authors: steger g. PLoS One. 2013 Sep 23;8(9):e74911. doi: 10.1371/journal.pone.0074911. eCollection 2013. PLoS One. 2013. PMID: 24086395 Free PMC article.
In cells that lack ZNF395, the IFN-alpha-mediated stimulation of these factors was impaired, demonstrating that ZNF395 is required for the full induction of these antiviral genes. ...Thus, ZNF395 becomes activated at the level of protein modification by IKK. …
In cells that lack ZNF395, the IFN-alpha-mediated stimulation of these factors was impaired, demonstrating that ZNF395 is requ …
The Transcription Factor ZNF395 Is Required for the Maximal Hypoxic Induction of Proinflammatory Cytokines in U87-MG Cells.
Herwartz C, Castillo-Juárez P, Schröder L, Barron BL, Steger G. Herwartz C, et al. Among authors: steger g. Mediators Inflamm. 2015;2015:804264. doi: 10.1155/2015/804264. Epub 2015 Jul 1. Mediators Inflamm. 2015. PMID: 26229239 Free PMC article.
We show that ZNF395 is a target gene of the hypoxia inducible factor HIF-1alpha. By gene expression analysis, RT-PCR and ELISA, we demonstrated that the siRNA-mediated suppression of ZNF395 impairs the hypoxic induction of IL-1beta, IL-6, IL-8, and LIF in U87-MG cel …
We show that ZNF395 is a target gene of the hypoxia inducible factor HIF-1alpha. By gene expression analysis, RT-PCR and ELISA, we de …
HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.
Kirschberg M, Heuser S, Syed AS, Steger G, Majewski S, Hufbauer M, Akgül B. Kirschberg M, et al. Among authors: steger g. Virology. 2019 Sep;535:136-143. doi: 10.1016/j.virol.2019.06.019. Epub 2019 Jul 1. Virology. 2019. PMID: 31299490 Free article.
The human papillomavirus type 8 (HPV8) is associated with skin cancer development. The goal of this study was to investigate the effects of HPV8 oncoproteins on cellular gene expression and the identification of key regulators. ...
The human papillomavirus type 8 (HPV8) is associated with skin cancer development. The goal of this study was to investigate the effe …
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P. Yao X, et al. Among authors: steger g. Cancer Discov. 2017 Nov;7(11):1284-1305. doi: 10.1158/2159-8290.CD-17-0375. Epub 2017 Sep 11. Cancer Discov. 2017. PMID: 28893800
Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enhancer malfunction in ccRCC, with cognate enhancer-target genes associated with tissue-specific aspects of malignancy. Superenhancer profiling identified ZNF395 a …
Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enhancer malfunction in ccRCC, …
Human papillomavirus type 8 E6 oncoprotein inhibits transcription of the PDZ protein syntenin-2.
Lazić D, Hufbauer M, Zigrino P, Buchholz S, Kazem S, Feltkamp MC, Mauch C, Steger G, Pfister H, Akgül B. Lazić D, et al. Among authors: steger g. J Virol. 2012 Aug;86(15):7943-52. doi: 10.1128/JVI.00132-12. Epub 2012 May 23. J Virol. 2012. PMID: 22623796 Free PMC article. Clinical Trial.
The E6 proteins from high-risk alpha human papillomavirus (HPV) types (e.g., HPV16) are characterized by the presence of a PDZ-binding motif through which they interact with a number of cellular PDZ domain-containing substrates and cooperate in their degradation. ...
The E6 proteins from high-risk alpha human papillomavirus (HPV) types (e.g., HPV16) are characterized by the presence of a PDZ-bindin …
Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.
Sichtig N, Körfer N, Steger G. Sichtig N, et al. Among authors: steger g. Arch Biochem Biophys. 2007 Nov 1;467(1):67-75. doi: 10.1016/j.abb.2007.08.015. Epub 2007 Aug 29. Arch Biochem Biophys. 2007. PMID: 17897615
Papillomavirus binding factor, PBF, identical to the Huntington's disease binding protein 2, HDBP2, is a nuclear-cytoplasmic shuttling factor with the ability to inhibit cell growth. It has been identified by its ability to bind to GC-rich sequence elements within upstream …
Papillomavirus binding factor, PBF, identical to the Huntington's disease binding protein 2, HDBP2, is a nuclear-cytoplasmic shuttlin …
Prevalence of antibodies to human papillomavirus type 8 in human sera.
Steger G, Olszewsky M, Stockfleth E, Pfister H. Steger G, et al. J Virol. 1990 Sep;64(9):4399-406. doi: 10.1128/JVI.64.9.4399-4406.1990. J Virol. 1990. PMID: 2166821 Free PMC article.
The epidermodysplasia verruciformis-associated human papillomavirus type 8 (HPV-8) poses a high risk for malignant conversion of skin lesions in patients with epidermodysplasia verruciformis. ...
The epidermodysplasia verruciformis-associated human papillomavirus type 8 (HPV-8) poses a high risk for malignant conversion of skin …
31 results