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A dramatic increase of C1q protein in the CNS during normal aging.
Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, Coutellier L, Kim L, Tsai HH, Huang EJ, Rowitch DH, Berns DS, Tenner AJ, Shamloo M, Barres BA. Stephan AH, et al. J Neurosci. 2013 Aug 14;33(33):13460-74. doi: 10.1523/JNEUROSCI.1333-13.2013. J Neurosci. 2013. PMID: 23946404 Free PMC article.
Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction.
Bolliger MF, Zurlinden A, Lüscher D, Bütikofer L, Shakhova O, Francolini M, Kozlov SV, Cinelli P, Stephan A, Kistler AD, Rülicke T, Pelczar P, Ledermann B, Fumagalli G, Gloor SM, Kunz B, Sonderegger P. Bolliger MF, et al. J Cell Sci. 2010 Nov 15;123(Pt 22):3944-55. doi: 10.1242/jcs.072090. Epub 2010 Oct 27. J Cell Sci. 2010. PMID: 20980386
Neurotrypsin cleaves agrin locally at the synapse.
Stephan A, Mateos JM, Kozlov SV, Cinelli P, Kistler AD, Hettwer S, Rülicke T, Streit P, Kunz B, Sonderegger P. Stephan A, et al. FASEB J. 2008 Jun;22(6):1861-73. doi: 10.1096/fj.07-100008. Epub 2008 Jan 29. FASEB J. 2008. PMID: 18230682
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