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CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].
Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, Hall JE. Wang MZ, et al. Among authors: stephens ce. Drug Metab Dispos. 2006 Dec;34(12):1985-94. doi: 10.1124/dmd.106.010587. Epub 2006 Sep 22. Drug Metab Dispos. 2006. PMID: 16997912 Free PMC article.
Novel arylimidamides for treatment of visceral leishmaniasis.
Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA. Wang MZ, et al. Among authors: stephens ce. Antimicrob Agents Chemother. 2010 Jun;54(6):2507-16. doi: 10.1128/AAC.00250-10. Epub 2010 Apr 5. Antimicrob Agents Chemother. 2010. PMID: 20368397 Free PMC article.
Aromatic diamidines as antiparasitic agents.
Soeiro MN, De Souza EM, Stephens CE, Boykin DW. Soeiro MN, et al. Among authors: stephens ce. Expert Opin Investig Drugs. 2005 Aug;14(8):957-72. doi: 10.1517/13543784.14.8.957. Expert Opin Investig Drugs. 2005. PMID: 16050790 Review.
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