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Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.
Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazaré Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, Boykin DW, Wang MZ, Werbovetz KA. Zhu X, et al. Among authors: stephens ce. Antimicrob Agents Chemother. 2012 Jul;56(7):3690-9. doi: 10.1128/AAC.06404-11. Epub 2012 Apr 16. Antimicrob Agents Chemother. 2012. PMID: 22508306 Free PMC article.
Novel arylimidamides for treatment of visceral leishmaniasis.
Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA. Wang MZ, et al. Among authors: stephens ce. Antimicrob Agents Chemother. 2010 Jun;54(6):2507-16. doi: 10.1128/AAC.00250-10. Epub 2010 Apr 5. Antimicrob Agents Chemother. 2010. PMID: 20368397 Free PMC article.
Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection.
da Silva CF, Batista DDGJ, de Araújo JS, Cunha-Junior EF, Stephens CE, Banerjee M, Farahat AA, Akay S, Fisher MK, Boykin DW, Soeiro MNC. da Silva CF, et al. Among authors: stephens ce. Drug Des Devel Ther. 2017 Apr 3;11:1095-1105. doi: 10.2147/DDDT.S120618. eCollection 2017. Drug Des Devel Ther. 2017. PMID: 28435221 Free PMC article.
In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi.
De Araújo JS, Da Silva CF, Batista DG, Da Silva PB, Meuser MB, Aiub CA, da Silva MF, Araújo-Lima CF, Banerjee M, Farahat AA, Stephens CE, Kumar A, Boykin DW, Soeiro MN. De Araújo JS, et al. Among authors: stephens ce. Antimicrob Agents Chemother. 2014 Jul;58(7):4191-5. doi: 10.1128/AAC.01403-13. Epub 2014 Mar 3. Antimicrob Agents Chemother. 2014. PMID: 24590476 Free PMC article.
Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.
Batista Dda G, Batista MM, de Oliveira GM, do Amaral PB, Lannes-Vieira J, Britto CC, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Boykin DW, Soeiro Mde N. Batista Dda G, et al. Among authors: stephens ce. Antimicrob Agents Chemother. 2010 Jul;54(7):2940-52. doi: 10.1128/AAC.01617-09. Epub 2010 May 10. Antimicrob Agents Chemother. 2010. PMID: 20457822 Free PMC article.
The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro.
DA Silva CF, Daliry A, DA Silva PB, Akay S, Banerjee M, Farahat AA, Fisher MK, Hu L, Kumar A, Liu Z, Stephens CE, Boykin DW, Correia Soeiro MD. DA Silva CF, et al. Among authors: stephens ce. Parasitology. 2011 Dec;138(14):1863-9. doi: 10.1017/S0031182011001429. Epub 2011 Sep 9. Parasitology. 2011. PMID: 21902869
The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA.
Daliry A, Pires MQ, Silva CF, Pacheco RS, Munde M, Stephens CE, Kumar A, Ismail MA, Liu Z, Farahat AA, Akay S, Som P, Hu Q, Boykin DW, Wilson WD, De Castro SL, Soeiro MN. Daliry A, et al. Among authors: stephens ce. Antimicrob Agents Chemother. 2011 Oct;55(10):4765-73. doi: 10.1128/AAC.00229-11. Epub 2011 Aug 1. Antimicrob Agents Chemother. 2011. PMID: 21807972 Free PMC article.
78 results