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Developing inhibitors to selectively target two-component and phosphorelay signal transduction systems of pathogenic microorganisms.
Stephenson K, Hoch JA. Stephenson K, et al. Curr Med Chem. 2004 Mar;11(6):765-73. doi: 10.2174/0929867043455765. Curr Med Chem. 2004. PMID: 15032730 Review.
Sec-dependent protein translocation across biological membranes: evolutionary conservation of an essential protein transport pathway (review).
Stephenson K. Stephenson K. Mol Membr Biol. 2005 Jan-Apr;22(1-2):17-28. doi: 10.1080/09687860500063308. Mol Membr Biol. 2005. PMID: 16092521 Review.
Histidine kinase-mediated signal transduction systems of pathogenic microorganisms as targets for therapeutic intervention.
Stephenson K, Hoch JA. Stephenson K, et al. Curr Drug Targets Infect Disord. 2002 Sep;2(3):235-46. doi: 10.2174/1568005023342443. Curr Drug Targets Infect Disord. 2002. PMID: 12462127 Review.
The mechanism of action of inhibitors of bacterial two-component signal transduction systems.
Stephenson K, Yamaguchi Y, Hoch JA. Stephenson K, et al. J Biol Chem. 2000 Dec 8;275(49):38900-4. doi: 10.1074/jbc.M006633200. J Biol Chem. 2000. PMID: 10978341
Dissection of the functional and structural domains of phosphorelay histidine kinase A of Bacillus subtilis.
Wang L, Fabret C, Kanamaru K, Stephenson K, Dartois V, Perego M, Hoch JA. Wang L, et al. Among authors: stephenson k. J Bacteriol. 2001 May;183(9):2795-802. doi: 10.1128/JB.183.9.2795-2802.2001. J Bacteriol. 2001. PMID: 11292798 Free PMC article.
Virulence- and antibiotic resistance-associated two-component signal transduction systems of Gram-positive pathogenic bacteria as targets for antimicrobial therapy.
Stephenson K, Hoch JA. Stephenson K, et al. Pharmacol Ther. 2002 Feb-Mar;93(2-3):293-305. doi: 10.1016/s0163-7258(02)00198-5. Pharmacol Ther. 2002. PMID: 12191621 Review.
Two-component and phosphorelay signal-transduction systems as therapeutic targets.
Stephenson K, Hoch JA. Stephenson K, et al. Curr Opin Pharmacol. 2002 Oct;2(5):507-12. doi: 10.1016/s1471-4892(02)00194-7. Curr Opin Pharmacol. 2002. PMID: 12324251 Review.
Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production.
Underwood S, Guan S, Vijayasubhash V, Baines SD, Graham L, Lewis RJ, Wilcox MH, Stephenson K. Underwood S, et al. Among authors: stephenson k. J Bacteriol. 2009 Dec;191(23):7296-305. doi: 10.1128/JB.00882-09. Epub 2009 Sep 25. J Bacteriol. 2009. PMID: 19783633 Free PMC article.
Evolution of signalling in the sporulation phosphorelay.
Stephenson K, Hoch JA. Stephenson K, et al. Mol Microbiol. 2002 Oct;46(2):297-304. doi: 10.1046/j.1365-2958.2002.03186.x. Mol Microbiol. 2002. PMID: 12406209 Review.
Molecular insights into the initiation of sporulation in Gram-positive bacteria: new technologies for an old phenomenon.
Stephenson K, Lewis RJ. Stephenson K, et al. FEMS Microbiol Rev. 2005 Apr;29(2):281-301. doi: 10.1016/j.femsre.2004.10.003. FEMS Microbiol Rev. 2005. PMID: 15808745 Review.
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