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Investigating human disease using stem cell models.
Sterneckert JL, Reinhardt P, Schöler HR. Sterneckert JL, et al. Nat Rev Genet. 2014 Sep;15(9):625-39. doi: 10.1038/nrg3764. Epub 2014 Jul 29. Nat Rev Genet. 2014. PMID: 25069490 Review.
Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells.
Greber B, Wu G, Bernemann C, Joo JY, Han DW, Ko K, Tapia N, Sabour D, Sterneckert J, Tesar P, Schöler HR. Greber B, et al. Cell Stem Cell. 2010 Mar 5;6(3):215-26. doi: 10.1016/j.stem.2010.01.003. Cell Stem Cell. 2010. PMID: 20207225
Neural induction intermediates exhibit distinct roles of Fgf signaling.
Sterneckert J, Stehling M, Bernemann C, Araúzo-Bravo MJ, Greber B, Gentile L, Ortmeier C, Sinn M, Wu G, Ruau D, Zenke M, Brintrup R, Klein DC, Ko K, Schöler HR. Sterneckert J, et al. Stem Cells. 2010 Oct;28(10):1772-81. doi: 10.1002/stem.498. Stem Cells. 2010. PMID: 20715182
Distinct developmental ground states of epiblast stem cell lines determine different pluripotency features.
Bernemann C, Greber B, Ko K, Sterneckert J, Han DW, Araúzo-Bravo MJ, Schöler HR. Bernemann C, et al. Stem Cells. 2011 Oct;29(10):1496-503. doi: 10.1002/stem.709. Stem Cells. 2011. PMID: 21898681
Concise review: Oct4 and more: the reprogramming expressway.
Sterneckert J, Höing S, Schöler HR. Sterneckert J, et al. Stem Cells. 2012 Jan;30(1):15-21. doi: 10.1002/stem.765. Stem Cells. 2012. PMID: 22009686 Review.
Zfp296 is a novel, pluripotent-specific reprogramming factor.
Fischedick G, Klein DC, Wu G, Esch D, Höing S, Han DW, Reinhardt P, Hergarten K, Tapia N, Schöler HR, Sterneckert JL. Fischedick G, et al. Among authors: sterneckert jl. PLoS One. 2012;7(4):e34645. doi: 10.1371/journal.pone.0034645. Epub 2012 Apr 2. PLoS One. 2012. PMID: 22485183 Free PMC article.
Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.
Höing S, Rudhard Y, Reinhardt P, Glatza M, Stehling M, Wu G, Peiker C, Böcker A, Parga JA, Bunk E, Schwamborn JC, Slack M, Sterneckert J, Schöler HR. Höing S, et al. Cell Stem Cell. 2012 Nov 2;11(5):620-32. doi: 10.1016/j.stem.2012.07.005. Epub 2012 Oct 11. Cell Stem Cell. 2012. PMID: 23064101
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.
Reinhardt P, Schmid B, Burbulla LF, Schöndorf DC, Wagner L, Glatza M, Höing S, Hargus G, Heck SA, Dhingra A, Wu G, Müller S, Brockmann K, Kluba T, Maisel M, Krüger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Müller H, Gasser T, Schöler HR, Sterneckert J. Reinhardt P, et al. Cell Stem Cell. 2013 Mar 7;12(3):354-67. doi: 10.1016/j.stem.2013.01.008. Cell Stem Cell. 2013. PMID: 23472874
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel CS, Höing S, Moritz S, Parga JA, Wagner L, Bruder JM, Wu G, Schmid B, Röpke A, Klingauf J, Schwamborn JC, Gasser T, Schöler HR, Sterneckert J. Reinhardt P, et al. PLoS One. 2013;8(3):e59252. doi: 10.1371/journal.pone.0059252. Epub 2013 Mar 22. PLoS One. 2013. PMID: 23533608 Free PMC article.
Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway.
Lojewski X, Staropoli JF, Biswas-Legrand S, Simas AM, Haliw L, Selig MK, Coppel SH, Goss KA, Petcherski A, Chandrachud U, Sheridan SD, Lucente D, Sims KB, Gusella JF, Sondhi D, Crystal RG, Reinhardt P, Sterneckert J, Schöler H, Haggarty SJ, Storch A, Hermann A, Cotman SL. Lojewski X, et al. Hum Mol Genet. 2014 Apr 15;23(8):2005-22. doi: 10.1093/hmg/ddt596. Epub 2013 Nov 23. Hum Mol Genet. 2014. PMID: 24271013 Free PMC article.
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