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Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).
Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose AJ, Park Y, Schultz PG, Horwich AL, Hoang QQ, Chapman E, Johnson SM. Abdeen S, et al. Among authors: stevens m. J Med Chem. 2018 Aug 23;61(16):7345-7357. doi: 10.1021/acs.jmedchem.8b00989. Epub 2018 Aug 14. J Med Chem. 2018. PMID: 30060666 Free PMC article.
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SM. Washburn A, et al. Among authors: stevens m. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1665-1672. doi: 10.1016/j.bmcl.2019.04.034. Epub 2019 Apr 24. Bioorg Med Chem Lett. 2019. PMID: 31047750 Free PMC article.
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
Stevens M, Howe C, Ray AM, Washburn A, Chitre S, Sivinski J, Park Y, Hoang QQ, Chapman E, Johnson SM. Stevens M, et al. Bioorg Med Chem. 2020 Nov 15;28(22):115710. doi: 10.1016/j.bmc.2020.115710. Epub 2020 Aug 30. Bioorg Med Chem. 2020. PMID: 33007545 Free PMC article.
Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL.
Sivinski J, Ambrose AJ, Panfilenko I, Zerio CJ, Machulis JM, Mollasalehi N, Kaneko LK, Stevens M, Ray AM, Park Y, Wu C, Hoang QQ, Johnson SM, Chapman E. Sivinski J, et al. Among authors: stevens m. mBio. 2021 Jan 12;12(1):e02167-20. doi: 10.1128/mBio.02167-20. mBio. 2021. PMID: 33436430 Free PMC article.
Allosteric differences dictate GroEL complementation of E. coli.
Sivinski J, Ngo D, Zerio CJ, Ambrose AJ, Watson ER, Kaneko LK, Kostelic MM, Stevens M, Ray AM, Park Y, Wu C, Marty MT, Hoang QQ, Zhang DD, Lander GC, Johnson SM, Chapman E. Sivinski J, et al. Among authors: stevens m. FASEB J. 2022 Mar;36(3):e22198. doi: 10.1096/fj.202101708RR. FASEB J. 2022. PMID: 35199390 Free PMC article.
Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.
Chitre S, Ray AM, Stevens M, Doud EH, Liechty H, Washburn A, Tepper K, Sivinski J, O'Hagan HM, Georgiadis MM, Chapman E, Johnson SM. Chitre S, et al. Among authors: stevens m. Bioorg Med Chem. 2022 Dec 1;75:117072. doi: 10.1016/j.bmc.2022.117072. Epub 2022 Oct 30. Bioorg Med Chem. 2022. PMID: 36356534
3,892 results