Stewart K - Search Results

1

Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents.

Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Stewart K, Navaza J, Payne CD, Ray TL. Abad-Zapatero C, et al. Among authors: stewart k. Protein Sci. 1996 Apr;5(4):640-52. doi: 10.1002/pro.5560050408. Protein Sci. 1996. PMID: 8845753 Free PMC article.

2

Structure of secreted aspartic proteinases from Candida. Implications for the design of antifungal agents.

Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Oie T, Stewart K, Cutfield SM, Cutfield JF, Foundling SI, Ray TL. Abad-Zapatero C, et al. Among authors: stewart k. Adv Exp Med Biol. 1998;436:297-313. doi: 10.1007/978-1-4615-5373-1_41. Adv Exp Med Biol. 1998. PMID: 9561233 Review.

3

Candida proteases and their inhibition: prospects for antifungal therapy.

Stewart K, Abad-Zapatero C. Stewart K, et al. Curr Med Chem. 2001 Jul;8(8):941-8. doi: 10.2174/0929867013372698. Curr Med Chem. 2001. PMID: 11375761 Review.

4

The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.

Schluckebier G, Zhong P, Stewart KD, Kavanaugh TJ, Abad-Zapatero C. Schluckebier G, et al. Among authors: stewart kd. J Mol Biol. 1999 Jun 4;289(2):277-91. doi: 10.1006/jmbi.1999.2788. J Mol Biol. 1999. PMID: 10366505

5

Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.

Stoll V, Stewart KD, Maring CJ, Muchmore S, Giranda V, Gu YG, Wang G, Chen Y, Sun M, Zhao C, Kennedy AL, Madigan DL, Xu Y, Saldivar A, Kati W, Laver G, Sowin T, Sham HL, Greer J, Kempf D. Stoll V, et al. Biochemistry. 2003 Jan 28;42(3):718-27. doi: 10.1021/bi0205449. Biochemistry. 2003. PMID: 12534284

6

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Wang GT, Chen Y, Wang S, Gentles R, Sowin T, Kati W, Muchmore S, Giranda V, Stewart K, Sham H, Kempf D, Laver WG. Wang GT, et al. Among authors: stewart k. J Med Chem. 2001 Apr 12;44(8):1192-201. doi: 10.1021/jm000468c. J Med Chem. 2001. PMID: 11312919

7

Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery.

Stewart KD, Steffy K, Harris K, Harlan JE, Stoll VS, Huth JR, Walter KA, Gramling-Evans E, Mendoza RR, Severin JM, Richardson PL, Barrett LW, Matayoshi ED, Swift KM, Betz SF, Muchmore SW, Kempf DJ, Molla A. Stewart KD, et al. J Comput Aided Mol Des. 2007 Jan-Mar;21(1-3):121-30. doi: 10.1007/s10822-007-9107-1. Epub 2007 Feb 9. J Comput Aided Mol Des. 2007. PMID: 17294246

8

Cheminformatic tools for medicinal chemists.

Muchmore SW, Edmunds JJ, Stewart KD, Hajduk PJ. Muchmore SW, et al. J Med Chem. 2010 Jul 8;53(13):4830-41. doi: 10.1021/jm100164z. J Med Chem. 2010. PMID: 20329801 No abstract available.

9

Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.

Gracias V, Ji Z, Akritopoulou-Zanze I, Abad-Zapatero C, Huth JR, Song D, Hajduk PJ, Johnson EF, Glaser KB, Marcotte PA, Pease L, Soni NB, Stewart KD, Davidsen SK, Michaelides MR, Djuric SW. Gracias V, et al. Among authors: stewart kd. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2691-5. doi: 10.1016/j.bmcl.2008.03.021. Epub 2008 Mar 10. Bioorg Med Chem Lett. 2008. PMID: 18362070

10

Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.

McClellan WJ, Dai Y, Abad-Zapatero C, Albert DH, Bouska JJ, Glaser KB, Magoc TJ, Marcotte PA, Osterling DJ, Stewart KD, Davidsen SK, Michaelides MR. McClellan WJ, et al. Among authors: stewart kd. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5620-4. doi: 10.1016/j.bmcl.2011.06.041. Epub 2011 Jun 29. Bioorg Med Chem Lett. 2011. PMID: 21778056

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