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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. Staus DP, et al. Among authors: steyaert j. Nature. 2016 Jul 21;535(7612):448-52. doi: 10.1038/nature18636. Epub 2016 Jul 13. Nature. 2016. PMID: 27409812 Free PMC article.
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK. Rasmussen SG, et al. Among authors: steyaert j. Nature. 2011 Jan 13;469(7329):175-80. doi: 10.1038/nature09648. Nature. 2011. PMID: 21228869 Free PMC article.
Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. Rasmussen SG, et al. Among authors: steyaert j. Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361. Nature. 2011. PMID: 21772288 Free PMC article.
Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.
Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL Jr, Steyaert J, Kobilka BK, Sunahara RK, Skiniotis G. Westfield GH, et al. Among authors: steyaert j. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16086-91. doi: 10.1073/pnas.1113645108. Epub 2011 Sep 13. Proc Natl Acad Sci U S A. 2011. PMID: 21914848 Free PMC article.
Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.
Sohier JS, Laurent C, Chevigné A, Pardon E, Srinivasan V, Wernery U, Lassaux P, Steyaert J, Galleni M. Sohier JS, et al. Among authors: steyaert j. Biochem J. 2013 Mar 15;450(3):477-86. doi: 10.1042/BJ20121305. Biochem J. 2013. PMID: 23289540 Free article.
422 results