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The immunological synapse of CTL contains a secretory domain and membrane bridges.
Stinchcombe JC, Bossi G, Booth S, Griffiths GM. Stinchcombe JC, et al. Immunity. 2001 Nov;15(5):751-61. doi: 10.1016/s1074-7613(01)00234-5. Immunity. 2001. PMID: 11728337
Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I.
Hanon E, Stinchcombe JC, Saito M, Asquith BE, Taylor GP, Tanaka Y, Weber JN, Griffiths GM, Bangham CR. Hanon E, et al. Among authors: stinchcombe jc. Immunity. 2000 Nov;13(5):657-64. doi: 10.1016/s1074-7613(00)00065-0. Immunity. 2000. PMID: 11114378
Normal and abnormal secretion by haemopoietic cells.
Stinchcombe JC, Griffiths GM. Stinchcombe JC, et al. Immunology. 2001 May;103(1):10-6. doi: 10.1046/j.1365-2567.2001.01225.x. Immunology. 2001. PMID: 11380687 Free PMC article. Review.
Secretory lysosome biogenesis in cytotoxic T lymphocytes from normal and Chediak Higashi syndrome patients.
Stinchcombe JC, Page LJ, Griffiths GM. Stinchcombe JC, et al. Traffic. 2000 May;1(5):435-44. doi: 10.1034/j.1600-0854.2000.010508.x. Traffic. 2000. PMID: 11208129
Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.
Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM. Jenkins MR, et al. Among authors: stinchcombe jc. Elife. 2014 Mar 4;3:e01310. doi: 10.7554/eLife.01310. Elife. 2014. PMID: 24596147 Free PMC article.
Secretory mechanisms in cell-mediated cytotoxicity.
Stinchcombe JC, Griffiths GM. Stinchcombe JC, et al. Annu Rev Cell Dev Biol. 2007;23:495-517. doi: 10.1146/annurev.cellbio.23.090506.123521. Annu Rev Cell Dev Biol. 2007. PMID: 17506701 Review.
The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.
Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM. Jenkins MR, et al. Among authors: stinchcombe jc. Immunity. 2009 Oct 16;31(4):621-31. doi: 10.1016/j.immuni.2009.08.024. Immunity. 2009. PMID: 19833087 Free PMC article.
Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.
Stinchcombe JC, Randzavola LO, Angus KL, Mantell JM, Verkade P, Griffiths GM. Stinchcombe JC, et al. Curr Biol. 2015 Dec 21;25(24):3239-44. doi: 10.1016/j.cub.2015.10.028. Epub 2015 Dec 5. Curr Biol. 2015. PMID: 26670998 Free PMC article.
Actin depletion initiates events leading to granule secretion at the immunological synapse.
Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM. Ritter AT, et al. Among authors: stinchcombe jc. Immunity. 2015 May 19;42(5):864-76. doi: 10.1016/j.immuni.2015.04.013. Immunity. 2015. PMID: 25992860 Free PMC article.
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems.
Stinchcombe JC, Salio M, Cerundolo V, Pende D, Arico M, Griffiths GM. Stinchcombe JC, et al. BMC Biol. 2011 Jun 28;9:45. doi: 10.1186/1741-7007-9-45. BMC Biol. 2011. PMID: 21711522 Free PMC article.
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